URV's Author/s: | Victoria Hernando, Belen Alejos, Susana Monge, Juan berenguer
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Author, as appears in the article.: | Hernando, V. Alejos, B. Monge, S. Berenguer, J. Anta, L. Vinuesa, D. Palacios, R. Muga, R. Moreno, S. Jarrin, I. and for CoRIS cohort
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Journal publication year: | 2013
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ISSN: | 1471-2334
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Abstract: | Background Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. Methods We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. Results Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997¿2003). Conclusion Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection.
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Article's DOI: | 10.1186/1471-2334-13-382
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Link to the original source: | http://www.biomedcentral.com/1471-2334/13/382
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Papper version: | info:eu-repo/semantics/publishedVersion
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licence for use: | https://creativecommons.org/licenses/by/3.0/es/
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Department: | Ciències Mèdiques Bàsiques
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Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/
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Entity: | Universitat Rovira i Virgili.
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First page: | 382
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Last page: | 388
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Journal volume: | 13
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