Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a model for metabolic syndrome

Molinar-Toribio, E. Pérez-Jiménez, J. Ramos-Romero, S. Lluís, L. Sánchez-Martos, V. Taltavull, N. Romeu, M. Pazos, M. Méndez, L. Miranda, A. Cascante, M. Medina, I. Torres, J.L.

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Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a model for metabolic syndrome - PC:943

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https://hdl.handle.net/20.500.11797/PC943

Autor/es de la URV:	Eunice Molinar-Toribio, Jara Pérez-Jiménez , Sara Ramos-Romero, Laura Lluís, Vanessa Sánchez-Martos, Núria Taltavull, Marta Romeu, Manuel Pazos, Lucía Méndez, Aníbal Miranda, Marta Cascante, Isabel Medina, Josep Lluís Torres
Autor según el artículo:	Molinar-Toribio, E. Pérez-Jiménez, J. Ramos-Romero, S. Lluís, L. Sánchez-Martos, V. Taltavull, N. Romeu, M. Pazos, M. Méndez, L. Miranda, A. Cascante, M. Medina, I. Torres, J.L.
Año de publicación de la revista:	2014
e-ISSN:	1932-6203
DOI del artículo:	https://doi.org/10.1371/journal.pone.0104637
Enlace a la fuente original:	http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0104637
Versión del articulo depositado:	info:eu-repo/semantics/publishedVersion
Acceso a la licencia de uso:	https://creativecommons.org/licenses/by/3.0/es/
Departamento:	Ciències Mèdiques Bàsiques
URL Documento de licencia:	https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad:	Universitat Rovira i Virgili.
Volumen de revista:	9

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Título:	Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a model for metabolic syndrome
Descripción:	SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, we extensively evaluate parameters related to CVD and oxidative stress (OS) in SHROB rats. SHROB rats were monitored for 15 weeks and compared to a control group of Wistar rats. Body weight was recorded weekly. At the end of the study, parameters related to CVD and OS were evaluated in plasma, urine and different organs. SHROB rats presented statistically significant differences from Wistar rats in CVD risk factors: total cholesterol, LDL-cholesterol, triglycerides, apoA1, apoB100, abdominal fat, insulin, blood pressure, C-reactive protein, ICAM-1 and PAI-1. In adipose tissue, liver and brain, the endogenous antioxidant systems were activated, yet there was no significant oxidative damage to lipids (MDA) or proteins (carbonylation). We conclude that SHROB rats present significant alterations in parameters related to inflammation, endothelial dysfunction, thrombotic activity, insulin resistance and OS measured in plasma as well as enhanced redox defence systems in vital organs that will be useful as markers of MetS and CVD for nutrition interventions.
Tipo:	Article info:eu-repo/semantics/publishedVersion
Coautor:	Ciències Mèdiques Bàsiques Universitat Rovira i Virgili.
Materia:	Síndrome metabòlica
Idioma:	a model for metabolic syndrome
Autor:	Molinar-Toribio, E. Pérez-Jiménez, J. Ramos-Romero, S. Lluís, L. Sánchez-Martos, V. Taltavull, N. Romeu, M. Pazos, M. Méndez, L. Miranda, A. Cascante, M. Medina, I. Torres, J.L.
Derechos:	info:eu-repo/semantics/openAccess
Fecha:	2014

TÍTULO:

https://hdl.handle.net/20.500.11797/PC943

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