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Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation - imarina:3084963

Autor/s de la URV:Fernandez Veledo, Sonia / Keiran Fernandez, Noelia Elisabeth / Maymo Masip, Elsa / Serena Perelló, Carolina / Terrón Puig, Margarida Maria / Vendrell Ortega, Juan José
Autor segons l'article:Serena C., Keiran N., Madeira A., Maymó-Masip E., Ejarque M., Terrón-Puig M., Espin E., Martí M., Borruel N., Guarner F., Menacho M., Zorzano A., Millan M., Fernández-Veledo S., Vendrell J.
Adreça de correu electrònic de l'autor:carolina.serena@urv.cat
elsa.maymo@urv.cat
margaridamaria.terron@estudiants.urv.cat
sonia.fernandez@urv.cat
juanjose.vendrell@urv.cat
Identificador de l'autor:0000-0002-9133-3120
0000-0003-2906-3788
0000-0002-6994-6115
Any de publicació de la revista:2017
Tipus de publicació:Journal Publications
ISSN:22136711
Referència de l'ítem segons les normes APA:Serena C., Keiran N., Madeira A., Maymó-Masip E., Ejarque M., Terrón-Puig M., Espin E., Martí M., Borruel N., Guarner F., Menacho M., Zorzano A., Mill (2017). Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation. Stem Cell Reports, 9(4), 1109-1123. DOI: 10.1016/j.stemcr.2017.07.014
Referència a l'article segons font original:Stem Cell Reports. 9 (4): 1109-1123
Resum:Crohn's disease (CD) is characterized by the expansion of mesenteric fat, also known as "creeping fat." We explored the plasticity and immune properties of adipose-derived stem cells (ASCs) in the context of CD as potential key players in the development of creeping fat. Mesenteric CD-derived ASCs presented a more proliferative, inflammatory, invasive, and phagocytic phenotype than equivalent cells from healthy donors, irrespective of the clinical stage. Remarkably, ASCs from the subcutaneous depot of patients with CD also showed an activated immune response that was associated with a reduction in their immunosuppressive properties. The invasive phenotype of mesenteric CD ASCs was governed by an inflammasome-mediated inflammatory state since blocking inflammasome signaling, mainly the secretion of interleukin-1?, reversed this characteristic. Thus, CD alters the biological functions of ASCs as adipocyte precursors, but also their immune properties. Selection of ASCs with the best immunomodulatory properties is advocated for the success of cell-based therapies.Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
DOI de l'article:10.1016/j.stemcr.2017.07.014
Enllaç font original:https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30324-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213671117303247%3Fshowall%3Dtrue
Versió de l'article dipositat:info:eu-repo/semantics/publishedVersion
Accès a la llicència d'ús:https://creativecommons.org/licenses/by/3.0/es/
Departament:Ciències Mèdiques Bàsiques
Bioquímica i Biotecnologia
URL Document de llicència:https://repositori.urv.cat/ca/proteccio-de-dades/
Àrees temàtiques:Medicina i
Genetics
Developmental biology
Cell biology
Cell & tissue engineering
Biochemistry
Paraules clau:Regulatory t cell
Regulatory t cell
Phagocytosis
Migration
Mesenchymal stem cells
Lymphocytes
Invasion
Interleukin 1b
Immunity
Creeping fat
Cell therapy
phagocytosis
migration
mesenchymal stem cells
lymphocytes
invasion
interleukin 1b
immunity
creeping fat
cell therapy
Entitat:Universitat Rovira i Virgili
Data d'alta del registre:2024-09-07
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