Repositori institucional URV
Español Català English
TÍTULO:
Classification of a hypervirulent aeromonas hydrophila pathotype responsible for epidemic outbreaks in warm-water fishes - imarina:3658158

Autor/es de la URV:Figueras Salvat, María Josefa
Autor según el artículo:Rasmussen-Ivey CR; Hossain MJ; Odom SE; Terhune JS; Hemstreet WG; Shoemaker CA; Zhang D; Xu DH; Griffin MJ; Liu YJ; Figueras MJ; Santos SR; Newton JC; Liles MR
Direcció de correo del autor:mariajose.figueras@urv.cat
Identificador del autor:0000-0002-2268-8980
Año de publicación de la revista:2016
Tipo de publicación:Journal Publications
ISSN:1664302X
Referencia de l'ítem segons les normes APA:Rasmussen-Ivey CR; Hossain MJ; Odom SE; Terhune JS; Hemstreet WG; Shoemaker CA; Zhang D; Xu DH; Griffin MJ; Liu YJ; Figueras MJ; Santos SR; Newton JC; (2016). Classification of a hypervirulent aeromonas hydrophila pathotype responsible for epidemic outbreaks in warm-water fishes. Frontiers In Microbiology, 7(OCT), 1615-. DOI: 10.3389/fmicb.2016.01615
Referencia al articulo segun fuente origial:Frontiers In Microbiology. 7 (OCT): 1615-
Resumen:Lineages of hypervirulent Aeromonas hydrophila (vAh) are the cause of persistent outbreaks of motile Aeromonas septicemia in warm-water fishes worldwide. Over the last decade, this virulent lineage of A. hydrophila has resulted in annual losses of millions of tons of farmed carp and catfish in the People's Republic of China and the United States (US). Multiple lines of evidence indicate US catfish and Asian carp isolates of A. hydrophila affiliated with sequence type 251 (ST251) share a recent common ancestor. To address the genomic context for the putative intercontinental transfer and subsequent geographic spread of this pathogen, we conducted a core genome phylogenetic analysis on 61 Aeromonas spp. genomes, of which 40 were affiliated with A. hydrophila, with 26 identified as epidemic strains. Phylogenetic analyses indicate all ST251 strains form a coherent lineage affiliated with A. hydrophila. Within this lineage, conserved genetic loci unique to A. hydrophila were identified, with some genes present in consistently higher copy numbers than in non-epidemic A. hydrophila isolates. In addition, results from analyses of representative ST251 isolates support the conclusion that multiple lineages are present within US vAh isolated from Mississippi, whereas vAh isolated from Alabama appear clonal. This is the first report of genomic heterogeneity within US vAh isolates, with some Mississippi isolates showing closer affiliation with the Asian grass carp isolate ZC1 than other vAh isolated in the US. To evaluate the biological significance of the identified heterogeneity, comparative disease challenges were conducted with representatives of different vAh genotypes. These studies revealed that isolate ZC1 yielded significantly lower mortality in channel catfish, relative to Alabama and Mississippi vAh isolates. Like other Asian vAh isolates, the ZC1 lineage contains all core genes for a complete type VI secretion system (T6SS). In contrast, more virulent US isolates retain only remnants of the T6SS (clpB, hcp, vgrG, and vasH) which may have functional implications. Collectively, these results characterize a hypervirulent A. hydrophila pathotype that affects farmed fish on multiple continents.
DOI del artículo:10.3389/fmicb.2016.01615
Enlace a la fuente original:https://www.frontiersin.org/articles/10.3389/fmicb.2016.01615/full
Versión del articulo depositado:info:eu-repo/semantics/publishedVersion
Acceso a la licencia de uso:https://creativecommons.org/licenses/by/3.0/es/
Departamento:Ciències Mèdiques Bàsiques
URL Documento de licencia:https://repositori.urv.cat/ca/proteccio-de-dades/
Áreas temáticas:Zootecnia / recursos pesqueiros
Saúde coletiva
Química
Odontología
Nutrição
Microbiology (medical)
Microbiology
Medicina veterinaria
Medicina ii
Medicina i
Materiais
Matemática / probabilidade e estatística
Interdisciplinar
Geografía
Geociências
Farmacia
Ensino
Engenharias iii
Engenharias ii
Engenharias i
Economia
Ciências biológicas iii
Ciências biológicas ii
Ciências biológicas i
Ciências ambientais
Ciências agrárias i
Ciência de alimentos
Ciência da computação
Biotecnología
Biodiversidade
Astronomia / física
Palabras clave:Pathogenesis
Emerging disease
Comparative genomics
Catfish, carp
Catfish
Bacteria
Aeromonas hydrophila
emerging disease
comparative genomics
catfish
carp
bacteria
aeromonas hydrophila
Entidad:Universitat Rovira i Virgili
Fecha de alta del registro:2023-02-22
Busca tu registro en:

Archivos desponibles
ArchivoDescripciónFormato
DocumentPrincipalDocumentPrincipalapplication/pdf

Información

© 2011 Universitat Rovira i Virgili