Repositori institucional URV
Español Català English
TÍTOL:
Null diffusion-based enrichment for metabolomics data - imarina:3715450

Autor/s de la URV:Rodríguez Chacón, Matilde / Vinaixa Crevillent, Maria / Yanes Torrado, Óscar
Autor segons l'article:Picart-Armada, Sergio; Fernandez-Albert, Francesc; Vinaixa, Maria; Rodriguez, Miguel A; Aivio, Suvi; Stracker, Travis H; Yanes, Oscar; Perera-Lluna, Alexandre
Adreça de correu electrònic de l'autor:maria.vinaixa@urv.cat
oscar.yanes@urv.cat
matilde.rodriguez@urv.cat
maria.vinaixa@urv.cat
Identificador de l'autor:0000-0001-9804-0171
0000-0003-3695-7157
0000-0001-9804-0171
Any de publicació de la revista:2017
Tipus de publicació:Journal Publications
ISSN:19326203
Referència de l'ítem segons les normes APA:Picart-Armada, Sergio; Fernandez-Albert, Francesc; Vinaixa, Maria; Rodriguez, Miguel A; Aivio, Suvi; Stracker, Travis H; Yanes, Oscar; Perera-Lluna, A (2017). Null diffusion-based enrichment for metabolomics data. Plos One, 12(12), 467-. DOI: 10.1371/journal.pone.0189012
Referència a l'article segons font original:Plos One. 12 (12): 467-
Resum:Metabolomics experiments identify metabolites whose abundance varies as the conditions under study change. Pathway enrichment tools help in the identification of key metabolic processes and in building a plausible biological explanation for these variations. Although several methods are available for pathway enrichment using experimental evidence, metabolomics does not yet have a comprehensive overview in a network layout at multiple molecular levels. We propose a novel pathway enrichment procedure for analysing summary metabolomics data based on sub-network analysis in a graph representation of a reference database. Relevant entries are extracted from the database according to statistical measures over a null diffusive process that accounts for network topology and pathway crosstalk. Entries are reported as a sub-pathway network, including not only pathways, but also modules, enzymes, reactions and possibly other compound candidates for further analyses. This provides a richer biological context, suitable for generating new study hypotheses and potential enzymatic targets. Using this method, we report results from cells depleted for an uncharacterised mitochondrial gene using GC and LC-MS data and employing KEGG as a knowledge base. Partial validation is provided with NMR-based tracking of 13C glucose labelling of these cells.
DOI de l'article:10.1371/journal.pone.0189012
Enllaç font original:https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189012
Versió de l'article dipositat:info:eu-repo/semantics/publishedVersion
Accès a la llicència d'ús:https://creativecommons.org/licenses/by/3.0/es/
Departament:Enginyeria Electrònica, Elèctrica i Automàtica
URL Document de llicència:https://repositori.urv.cat/ca/proteccio-de-dades/
Àrees temàtiques:Zootecnia / recursos pesqueiros
Sociology
Sociología
Serviço social
Saúde coletiva
Química
Psychology
Psicología
Planejamento urbano e regional / demografia
Odontología
Nutrição
Multidisciplinary sciences
Multidisciplinary
Medicine (miscellaneous)
Medicina veterinaria
Medicina iii
Medicina ii
Medicina i
Materiais
Matemática / probabilidade e estatística
Linguística e literatura
Letras / linguística
Interdisciplinary research in the social sciences
Interdisciplinar
Human geography and urban studies
History & philosophy of science
Historia
Geografía
Geociências
General medicine
General biochemistry,genetics and molecular biology
General agricultural and biological sciences
Farmacia
Environmental studies
Ensino
Engenharias iv
Engenharias iii
Engenharias ii
Engenharias i
Enfermagem
Educação física
Educação
Economia
Direito
Demography
Comunicação e informação
Ciências sociais aplicadas i
Ciências biológicas iii
Ciências biológicas ii
Ciências biológicas i
Ciências ambientais
Ciências agrárias i
Ciência política e relações internacionais
Ciência de alimentos
Ciência da computação
Biotecnología
Biology
Biodiversidade
Biochemistry, genetics and molecular biology (miscellaneous)
Astronomia / física
Arquitetura, urbanismo e design
Archaeology
Antropologia / arqueologia
Anthropology
Agricultural and biological sciences (miscellaneous)
Administração, ciências contábeis e turismo
Administração pública e de empresas, ciências contábeis e turismo
Paraules clau:Tool
Pathways
Lc/ms
Entitat:Universitat Rovira i Virgili
Data d'alta del registre:2024-10-12
Cerca el teu registre a:

Fitxers disponibles
FitxerDescripcióFormat
DocumentPrincipalDocumentPrincipalapplication/pdf

Informació

© 2011 Universitat Rovira i Virgili