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Voriconazole minimum inhibitory concentrations are predictive of treatment outcome in experimental murine infections by Candida glabrata - imarina:5129738

Autor/es de la URV:Capilla Luque, Javier / Guarro Artigas, Josep / Sanchis Talón, Marta
Autor según el artículo:Sanchis, Marta; Capilla, Javier; Castanheira, Mariana; Martin-Vicente, Adela; Sutton, Deanna A; Fothergill, Annette W; Wiederhold, Nathan P; Guarro, Josep
Direcció de correo del autor:marta.sanchis@urv.cat
javier.capilla@urv.cat
Identificador del autor:0000-0001-7251-6792
0000-0002-0765-6403
Año de publicación de la revista:2016
Tipo de publicación:Journal Publications
ISSN:09248579
Referencia de l'ítem segons les normes APA:Sanchis, Marta; Capilla, Javier; Castanheira, Mariana; Martin-Vicente, Adela; Sutton, Deanna A; Fothergill, Annette W; Wiederhold, Nathan P; Guarro, J (2016). Voriconazole minimum inhibitory concentrations are predictive of treatment outcome in experimental murine infections by Candida glabrata. International Journal Of Antimicrobial Agents, 47(4), 286-288. DOI: 10.1016/j.ijantimicag.2015.12.020
Referencia al articulo segun fuente origial:International Journal Of Antimicrobial Agents. 47 (4): 286-288
Resumen:In this study, 27 clinical isolates of Candida glabrata with voriconazole (VRC) minimum inhibitory concentrations (MICs) ranging from ¿0.03 ¿g/mL to 8 ¿g/mL were tested to determine whether in vitro data are predictive of in vivo efficacy. The efficacy of VRC administered at 40 mg/kg was assayed in a neutropenic murine model of disseminated infection by C. glabrata. The reduction in fungal tissue burden in the kidneys was used as a marker of treatment efficacy. VRC reduced the fungal tissue burden in mice infected with strains that had MICs below the epidemiological cut-off value (ECV) of 0.25 ¿g/mL. Variable efficacy of VRC was obtained when the MIC equalled the ECV, and VRC was ineffective when the MIC exceeded the ECV. These results suggest that the use of in vitro data could be useful to predict the outcome for infections by this fungus.
DOI del artículo:10.1016/j.ijantimicag.2015.12.020
Enlace a la fuente original:https://www.sciencedirect.com/science/article/abs/pii/S0924857916000431?via%3Dihub
Versión del articulo depositado:info:eu-repo/semantics/acceptedVersion
Acceso a la licencia de uso:https://creativecommons.org/licenses/by/3.0/es/
Departamento:Ciències Mèdiques Bàsiques
URL Documento de licencia:https://repositori.urv.cat/ca/proteccio-de-dades/
Áreas temáticas:Saúde coletiva
Química
Pharmacology (medical)
Pharmacology & pharmacy
Odontología
Nutrição
Microbiology (medical)
Microbiology
Medicine (miscellaneous)
Medicina veterinaria
Medicina iii
Medicina ii
Medicina i
Materiais
Interdisciplinar
Infectious diseases
General medicine
Farmacia
Engenharias iii
Engenharias ii
Enfermagem
Ciências biológicas iii
Ciências biológicas ii
Ciências biológicas i
Ciências ambientais
Ciências agrárias i
Biotecnología
Biodiversidade
Palabras clave:Voriconazole
Treatment outcome
Resistance
Model
Microbial sensitivity tests
Mice
Mechanisms
Management
Male
Liposomal amphotericin-b
Kidney
Fungal infection
Fluconazole
Fks mutations
Epidemiological cut-off value
Efficacy
Disease models, animal
Combination
Colony count, microbial
Caspofungin
Candidiasis
Candida glabrata
Antifungals
Antifungal agents
Animals
Animal model
fungal infection
epidemiological cut-off value
candida glabrata
antifungals
animal model
Entidad:Universitat Rovira i Virgili
Fecha de alta del registro:2025-01-08
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