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Grape-seed proanthocyanidins are able to reverse intestinal dysfunction and metabolic endotoxemia induced by a cafeteria diet in wistar rats - imarina:5658592

Autor/es de la URV:Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GINÉS MIR, IRIS / GONZALEZ QUILEN, CARLOS ALBERTO / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
Autor según el artículo:Gonzalez-Quilen, Carlos; Gil-Cardoso, Katherine; Gines, Iris; Beltran-Debon, Raul; Pinent, Montserrat; Ardevol, Anna; Terra, Ximena; Blay, M Teresa
Direcció de correo del autor:anna.ardevol@urv.cat
ximena.terra@urv.cat
mteresa.blay@urv.cat
montserrat.pinent@urv.cat
raul.beltran@urv.cat
Identificador del autor:0000-0003-0156-7538
0000-0003-1043-5844
0000-0002-6256-9847
0000-0003-3550-5378
0000-0001-9691-1906
Año de publicación de la revista:2019
Tipo de publicación:Journal Publications
ISSN:20726643
e-ISSN:2072-6643
Referencia de l'ítem segons les normes APA:Gonzalez-Quilen, Carlos; Gil-Cardoso, Katherine; Gines, Iris; Beltran-Debon, Raul; Pinent, Montserrat; Ardevol, Anna; Terra, Ximena; Blay, M Teresa (2019). Grape-seed proanthocyanidins are able to reverse intestinal dysfunction and metabolic endotoxemia induced by a cafeteria diet in wistar rats. Nutrients, 11(5), 979-. DOI: 10.3390/nu11050979
Referencia al articulo segun fuente origial:Nutrients. 11 (5): 979-
Resumen:© 2019 by the authors. Licensee MDPI, Basel, Switzerland. We evaluated the effectiveness of pharmacological doses of grape-seed proanthocyanidin extract (GSPE) in reversing intestinal barrier alterations and local inflammation in female Wistar rats fed a long-term obesogenic diet. Animals were fed a 17-week cafeteria diet (CAF diet), supplemented with daily GSPE doses (100 or 500 mg kg-1 body weight) during the final two weeks. CAF diet enhanced the intestinal permeation of an orally administered marker (ovalbumin, OVA) and increased the plasma levels of tumor necrosis factor-α (TNF-α) and lipopolysaccharides (LPS) in 2-3-fold. Ex vivo Ussing chamber assays showed a 55-70% reduction in transepithelial electrical resistance (TEER) and increased the TNF-α secretions in both small and large intestinal sections with a 25-fold increment in the ileum. Ileal tissues also presented a 4-fold increase of myeloperoxidase (MPO) activity. Both GSPE-treatments were able to restitute TEER values in the ileum and colon and to reduce plasma LPS to basal levels without a dose-dependent effect. However, effects on the OVA permeation and TNF-α secretion were dose and section-specific. GSPE also reduced ileal MPO activity and upregulated claudin 1 gene expression. This study provides evidence of the efficacy of GSPE-supplementation ameliorating diet-induced intestinal dysfunction and metabolic endotoxemia when administered at the end of a long-term obesogenic diet.
DOI del artículo:10.3390/nu11050979
Enlace a la fuente original:https://www.mdpi.com/2072-6643/11/5/979
Versión del articulo depositado:info:eu-repo/semantics/publishedVersion
Acceso a la licencia de uso:https://creativecommons.org/licenses/by/3.0/es/
Departamento:Bioquímica i Biotecnologia
URL Documento de licencia:https://repositori.urv.cat/ca/proteccio-de-dades/
Áreas temáticas:Zootecnia / recursos pesqueiros
Saúde coletiva
Química
Psicología
Planejamento urbano e regional / demografia
Nutrition and dietetics
Nutrition & dietetics
Nutrição
Medicina veterinaria
Medicina iii
Medicina ii
Medicina i
Interdisciplinar
Food science
Farmacia
Engenharias iv
Engenharias ii
Enfermagem
Educação física
Economia
Ciências biológicas iii
Ciências biológicas ii
Ciências biológicas i
Ciências agrárias i
Ciência de alimentos
Biotecnología
Palabras clave:Vitis
Ussing chamber
Transepithelial electrical resistance
Tight junction
Supplementation
Seeds
Rich
Rats, wistar
Rats
Proanthocyanidins
Obesity
Liver
Intestinal diseases
Insulin-resistance
Inflammation
High-fat diet
Gut microbiota
Gut
Flavan-3-ol
Female
Extract
Endotoxemia
Dose-response relationship, drug
Diet
Barrier function
Animals
ussing chamber
tight junction
obesity
inflammation
gut
flavan-3-ol
Entidad:Universitat Rovira i Virgili
Fecha de alta del registro:2024-10-19
Volumen de revista:11
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