Repositori institucional URV
| Autor/s de la URV: | Correig Blanchar, Francesc Xavier / FERRÉ VALLÈS, RAIMON / Girona Tell, Josefa / HERAS IBAÑEZ, MERCEDES / Masana Marín, Luis / Plana Gil, Núria / Rodríguez Borjabad, Cèlia |
| Autor segons l'article: | Girona, Josefa; Amigo, Nuria; Ibarretxe, Daiana; Plana, Nuria; Rodriguez-Borjabad, Celia; Heras, Mercedes; Ferre, Raimon; Gil, Miriam; Correig, Xavier; Masana, Lluis |
| Adreça de correu electrònic de l'autor: | luis.masana@urv.cat celia.rodriguez@urv.cat josefa.girona@urv.cat celia.rodriguez@urv.cat josefa.girona@urv.cat xavier.correig@urv.cat |
| Identificador de l'autor: | 0000-0002-0789-4954 0000-0001-8160-3716 0000-0002-6267-8779 0000-0001-8160-3716 0000-0002-6267-8779 0000-0002-6902-3054 |
| Any de publicació de la revista: | 2019 |
| Tipus de publicació: | Journal Publications |
| ISSN: | 14220067 |
| e-ISSN: | 1422-0067 |
| Referència de l'ítem segons les normes APA: | Girona, Josefa; Amigo, Nuria; Ibarretxe, Daiana; Plana, Nuria; Rodriguez-Borjabad, Celia; Heras, Mercedes; Ferre, Raimon; Gil, Miriam; Correig, Xavier (2019). HDL Triglycerides: A New Marker of Metabolic and Cardiovascular Risk.. International Journal Of Molecular Sciences, 20(13), 3151-. DOI: 10.3390/ijms20133151 |
| Referència a l'article segons font original: | International Journal Of Molecular Sciences. 20 (13): 3151- |
| Resum: | While cholesterol content in high-density lipoproteins (HDLs) is a well-established inverse marker of cardiovascular risk, the importance of HDL-triglyceride (HDL-TG) concentration is not well known. We aim to examine plasma HDL-TG concentrations, assessed by 1H-NMR, in patients with metabolic diseases and their association with classical biomarkers. In this cross-sectional study, we included 502 patients with type 2 diabetes or metabolic syndrome attending the lipid unit of our University Hospital. The presence of arteriosclerotic plaques was assessed by ultrasonography. A complete lipoprotein profile was performed by 1H-NMR (Liposcale test). HDL-TG was strongly positively correlated with total triglycerides, glycerol, and fatty liver index, while a strong negative correlation was observed with HDL-cholesterol (HDL-C) and HDL-particle number (HDL-P). HDL-TG was associated with all triglyceride-rich lipoprotein parameters and had an opposite association with HDL-C and HDL-P. It was also significantly correlated with circulating cholesterol ester transfer protein (CETP). HDL-TG concentrations were higher as metabolic syndrome components increased. HDL-TG was also higher with worsening glucose metabolism. Patients with carotid plaques also showed higher HDL-TG. In contrast to HDL-C, HDL-TG is directly associated with metabolism and arteriosclerotic vascular alterations. HDL-TG should be considered a biomarker of metabolic and cardiovascular risk and could be a marker of HDL dysfunction. |
| DOI de l'article: | 10.3390/ijms20133151 |
| Enllaç font original: | https://www.mdpi.com/1422-0067/20/13/3151 |
| Versió de l'article dipositat: | info:eu-repo/semantics/publishedVersion |
| Accès a la llicència d'ús: | https://creativecommons.org/licenses/by/3.0/es/ |
| Departament: | Ciències Mèdiques Bàsiques Medicina i Cirurgia |
| URL Document de llicència: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Àrees temàtiques: | Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física |
| Paraules clau: | Triglycerides Remnant cholesterol Ratio Normal-weight Myocardial-infarction Mortality Middle aged Metabolic syndrome Male Lipoproteins, hdl Lipids Insulin-resistance Humans Hdl-triglyceride Hdl triglycerides Hdl particle number Hdl cholesterol H-1-nmr Fenofibrate therapy Female Diabetes-mellitus Density-lipoprotein cholesterol Cardiovascular risk Cardiovascular diseases Biomarkers Aged 1h-nmr 1 h-nmr hdl triglycerides hdl particle number hdl cholesterol 1h-nmr |
| Entitat: | Universitat Rovira i Virgili |
| Data d'alta del registre: | 2024-08-10 |
| Volum de revista: | 20 |
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| Fitxer | Descripció | Format | |
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| DocumentPrincipal | DocumentPrincipal | application/pdf |
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