Repositori institucional URV
| Autor/es de la URV: | Ardévol Grau, Anna / Blay Olivé, Maria Teresa / CASANOVA MARTÍ, ANGELA / GINÉS MIR, IRIS / Pinent Armengol, Montserrat / Terra Barbadora, Ximena |
| Autor según el artículo: | Ginés, I; Gil-Cardoso, K; Serrano, J; Casanova-Marti, A; Lobato, M; Terra, X; Blay, MT; Ardévol, A; Pinent, M |
| Direcció de correo del autor: | anna.ardevol@urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat mteresa.blay@urv.cat montserrat.pinent@urv.cat montserrat.pinent@urv.cat |
| Identificador del autor: | 0000-0003-0156-7538 0000-0003-0156-7538 0000-0003-1043-5844 0000-0003-1043-5844 0000-0002-6256-9847 0000-0002-6256-9847 0000-0003-3550-5378 0000-0003-3550-5378 |
| Año de publicación de la revista: | 2019-08-01 |
| Tipo de publicación: | Journal Publications |
| ISSN: | 20734425 |
| e-ISSN: | 2073-4425 |
| Referencia de l'ítem segons les normes APA: | Ginés, I; Gil-Cardoso, K; Serrano, J; Casanova-Marti, A; Lobato, M; Terra, X; Blay, MT; Ardévol, A; Pinent, M (2019). Proanthocyanidins Limit Adipose Accrual Induced by a Cafeteria Diet, Several Weeks after the End of the Treatment.. Genes, 10(8), 598-. DOI: 10.3390/genes10080598 |
| Referencia al articulo segun fuente origial: | Genes. 10 (8): 598- |
| Resumen: | A dose of proanthocyanidins with satiating properties proved to be able to limit body weight increase several weeks after administration under exposure to a cafeteria diet. Here we describe some of the molecular targets and the duration of the effects. We treated rats with 500 mg grape seed proanthocyanidin extract (GSPE)/kg BW for ten days. Seven or seventeen weeks after the last GSPE dose, while animals were on a cafeteria diet, we used reverse transcriptase-polymerase chain reaction (RT-PCR) to measure the mRNA of the key energy metabolism enzymes from the liver, adipose depots and muscle. We found that a reduction in the expression of adipose Lpl might explain the lower amount of adipose tissue in rats seven weeks after the last GSPE dose. The liver showed increased expression of Cpt1a and Hmgs2 together with a reduction in Fasn and Dgat2. In addition, muscle showed a higher fatty oxidation (Oxct1 and Cpt1b mRNA). However, after seventeen weeks, there was a completely different gene expression pattern. At the conclusion of the study, seven weeks after the last GSPE administration there was a limitation in adipose accrual that might be mediated by an inhibition of the gene expression of the adipose tissue Lpl. Concomitantly there was an increase in fatty acid oxidation in liver and muscle. |
| DOI del artículo: | 10.3390/genes10080598 |
| Enlace a la fuente original: | https://www.mdpi.com/2073-4425/10/8/598 |
| Versión del articulo depositado: | info:eu-repo/semantics/publishedVersion |
| Acceso a la licencia de uso: | https://creativecommons.org/licenses/by/3.0/es/ |
| Departamento: | Bioquímica i Biotecnologia |
| URL Documento de licencia: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Áreas temáticas: | Medicina ii Medicina i Genetics (clinical) Genetics & heredity Genetics Biodiversidade |
| Palabras clave: | Vitis Rats Rat Proanthocyanidins Proanthocyanidin Overweight Muscle, skeletal Lpl Long-lasting effect Liver Leptin Keywords Female Fatty acid synthase, type i Fasn protein, rat Diet, western Diet, carbohydrate loading Diacylglycerol o-acyltransferase Dgat2 protein, rat Coenzyme a-transferases Carnitine o-palmitoyltransferase Appetite depressants Animals Adiposity Adipose tissue 3-ketoacid coa-transferase proanthocyanidin lpl long-lasting effect keywords adiposity |
| Entidad: | Universitat Rovira i Virgili |
| Fecha de alta del registro: | 2026-05-09 |
| Volumen de revista: | 10 |
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| DocumentPrincipal | DocumentPrincipal | application/pdf |
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