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Proanthocyanidins Limit Adipose Accrual Induced by a Cafeteria Diet, Several Weeks after the End of the Treatment. - imarina:5798791

Autor/es de la URV:Ardévol Grau, Anna / Blay Olivé, Maria Teresa / CASANOVA MARTÍ, ANGELA / GINÉS MIR, IRIS / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
Autor según el artículo:Gines, Iris; Gil-Cardoso, Katherine; Serrano, Joan; Casanova-Marti, Angela; Lobato, Maria; Terra, Ximena; Blay, M Teresa; Ardevol, Anna; Pinent, Montserrat
Direcció de correo del autor:anna.ardevol@urv.cat
ximena.terra@urv.cat
mteresa.blay@urv.cat
montserrat.pinent@urv.cat
Identificador del autor:0000-0003-0156-7538
0000-0003-1043-5844
0000-0002-6256-9847
0000-0003-3550-5378
Año de publicación de la revista:2019
Tipo de publicación:Journal Publications
ISSN:20734425
e-ISSN:2073-4425
Referencia de l'ítem segons les normes APA:Gines, Iris; Gil-Cardoso, Katherine; Serrano, Joan; Casanova-Marti, Angela; Lobato, Maria; Terra, Ximena; Blay, M Teresa; Ardevol, Anna; Pinent, Monts (2019). Proanthocyanidins Limit Adipose Accrual Induced by a Cafeteria Diet, Several Weeks after the End of the Treatment.. Genes, 10(8), 598-. DOI: 10.3390/genes10080598
Referencia al articulo segun fuente origial:Genes. 10 (8): 598-
Resumen:A dose of proanthocyanidins with satiating properties proved to be able to limit body weight increase several weeks after administration under exposure to a cafeteria diet. Here we describe some of the molecular targets and the duration of the effects. We treated rats with 500 mg grape seed proanthocyanidin extract (GSPE)/kg BW for ten days. Seven or seventeen weeks after the last GSPE dose, while animals were on a cafeteria diet, we used reverse transcriptase-polymerase chain reaction (RT-PCR) to measure the mRNA of the key energy metabolism enzymes from the liver, adipose depots and muscle. We found that a reduction in the expression of adipose Lpl might explain the lower amount of adipose tissue in rats seven weeks after the last GSPE dose. The liver showed increased expression of Cpt1a and Hmgs2 together with a reduction in Fasn and Dgat2. In addition, muscle showed a higher fatty oxidation (Oxct1 and Cpt1b mRNA). However, after seventeen weeks, there was a completely different gene expression pattern. At the conclusion of the study, seven weeks after the last GSPE administration there was a limitation in adipose accrual that might be mediated by an inhibition of the gene expression of the adipose tissue Lpl. Concomitantly there was an increase in fatty acid oxidation in liver and muscle.
DOI del artículo:10.3390/genes10080598
Enlace a la fuente original:https://www.mdpi.com/2073-4425/10/8/598
Versión del articulo depositado:info:eu-repo/semantics/publishedVersion
Acceso a la licencia de uso:https://creativecommons.org/licenses/by/3.0/es/
Departamento:Bioquímica i Biotecnologia
URL Documento de licencia:https://repositori.urv.cat/ca/proteccio-de-dades/
Áreas temáticas:Medicina ii
Medicina i
Matemática / probabilidade e estatística
Genetics (clinical)
Genetics & heredity
Genetics
Ciências biológicas iii
Ciências biológicas ii
Ciências biológicas i
Ciência da computação
Biotecnología
Biodiversidade
Palabras clave:Vitis
Rats
Rat
Proanthocyanidins
Proanthocyanidin
Overweight
Muscle, skeletal
Lpl
Long-lasting effect
Liver
Leptin
Keywords
Female
Fatty acid synthase, type i
Fasn protein, rat
Diet, western
Diet, carbohydrate loading
Diacylglycerol o-acyltransferase
Dgat2 protein, rat
Coenzyme a-transferases
Carnitine o-palmitoyltransferase
Appetite depressants
Animals
Adiposity
Adipose tissue
3-ketoacid coa-transferase
proanthocyanidin
lpl
long-lasting effect
keywords
adiposity
Entidad:Universitat Rovira i Virgili
Fecha de alta del registro:2024-10-26
Volumen de revista:10
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