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Evaluation of cytokeratin-19 in breast cancer tissue samples: A comparison of automatic and manual evaluations of scanned tissue microarray cylinders - imarina:6388522

Autor/es de la URV:Bosch Príncep, Ramon / Lejeune, Marylène Marie / López Navarro, Carolina / Lopez Pablo, Carlos
Autor según el artículo:Callau, Cristina; Lejeune, Marylene; Korzynska, Anna; Garcia, Marcial; Bueno, Gloria; Bosch, Ramon; Jaen, Joaquin; Orero, Guifre; Salvado, Teresa; Lopez, Carlos
Direcció de correo del autor:ramon.bosch@urv.cat
carlos.lopez@urv.cat
carolina.lopez@urv.cat
marylenemarie.lejeune@urv.cat
ramon.bosch@urv.cat
Identificador del autor:0000-0003-1248-3065
0000-0001-8441-9404
Año de publicación de la revista:2015
Tipo de publicación:Journal Publications
ISSN:1475925X
Referencia de l'ítem segons les normes APA:Callau, Cristina; Lejeune, Marylene; Korzynska, Anna; Garcia, Marcial; Bueno, Gloria; Bosch, Ramon; Jaen, Joaquin; Orero, Guifre; Salvado, Teresa; Lop (2015). Evaluation of cytokeratin-19 in breast cancer tissue samples: A comparison of automatic and manual evaluations of scanned tissue microarray cylinders. Biomedical Engineering Online, 14(2), S2-. DOI: 10.1186/1475-925X-14-S2-S2
Referencia al articulo segun fuente origial:Biomedical Engineering Online. 14 (2): S2-
Resumen:© 2015 Callau et al. Background: Digital image (DI) analysis avoids visual subjectivity in interpreting immunohistochemical stains and provides more reproducible results. An automated procedure consisting of two variant methods for quantifying the cytokeratin-19 (CK19) marker in breast cancer tissues is presented. Methods: The first method (A) excludes the holes inside selected CK19 stained areas, and the second (B) includes them. 93 DIs scanned from complete cylinders of tissue microarrays were evaluated visually by two pathologists and by the automated procedures. Results and conclusions: There was good concordance between the two automated methods, both of which tended to identify a smaller CK19-positive area than did the pathologists. The results obtained with method B were more similar to those of the pathologists; probably because it takes into account the entire positive tumoural area, including the holes. However, the pathologists overestimated the positive area of CK19. Further studies are needed to confirm the utility of this automated procedure in prognostic studies.
DOI del artículo:10.1186/1475-925X-14-S2-S2
Enlace a la fuente original:https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/1475-925X-14-S2-S2
Versión del articulo depositado:info:eu-repo/semantics/publishedVersion
Acceso a la licencia de uso:https://creativecommons.org/licenses/by/3.0/es/
Departamento:Ciències Mèdiques Bàsiques
URL Documento de licencia:https://repositori.urv.cat/ca/proteccio-de-dades/
Áreas temáticas:Saúde coletiva
Radiology, nuclear medicine and imaging
Radiological and ultrasound technology
Psicología
Odontología
Medicine (miscellaneous)
Medicina iii
Medicina ii
Medicina i
Interdisciplinar
Engineering, biomedical
Engenharias iv
Engenharias iii
Educação física
Ciências biológicas ii
Ciências biológicas i
Ciência da computação
Biotecnología
Biomedical engineering
Biomaterials
Astronomia / física
Administração pública e de empresas, ciências contábeis e turismo
Palabras clave:Tumour markers
Tissue array analysis
Observer variation
Keratin-19
Immunohistochemistry
Image processing, computer-assisted
Image processing
Humans
Breast neoplasms
Biomarkers, tumor
Automation
Algorithms
Entidad:Universitat Rovira i Virgili
Fecha de alta del registro:2024-10-12
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