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Effects of flavanols on enteroendocrine secretion - imarina:6406113

Autor/s de la URV:Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GONZALEZ QUILEN, CARLOS ALBERTO / Jorba Martin, Rosa Maria / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
Autor segons l'article:Grau-Bove, Carme; Gonzalez-Quilen, Carlos; Terra, Ximena; Blay, M Teresa; Beltran-Debon, Raul; Jorba-Martin, Rosa; Espina, Beatriz; Pinent, Montserrat; Ardevol, Anna
Adreça de correu electrònic de l'autor:anna.ardevol@urv.cat
ximena.terra@urv.cat
mteresa.blay@urv.cat
montserrat.pinent@urv.cat
rosamaria.jorba@urv.cat
raul.beltran@urv.cat
Identificador de l'autor:0000-0003-0156-7538
0000-0003-1043-5844
0000-0002-6256-9847
0000-0003-3550-5378
0000-0003-3307-4340
0000-0001-9691-1906
Any de publicació de la revista:2020
Tipus de publicació:Journal Publications
ISSN:2218273X
Referència de l'ítem segons les normes APA:Grau-Bove, Carme; Gonzalez-Quilen, Carlos; Terra, Ximena; Blay, M Teresa; Beltran-Debon, Raul; Jorba-Martin, Rosa; Espina, Beatriz; Pinent, Montserrat (2020). Effects of flavanols on enteroendocrine secretion. Biomolecules, 10(6), 1-14. DOI: 10.3390/biom10060844
Referència a l'article segons font original:Biomolecules. 10 (6): 1-14
Resum:© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Some beneficial effects of grape seed proanthocyanidin extract (GSPE) can be explained by the modulation of enterohormone secretion. As GSPE comprises a combination of different molecules, the pure compounds that cause these effects need to be elucidated. The enterohormones and chemoreceptors present in the gastrointestinal tract differ between species, so if humans are to gain beneficial effects, species closer to humans—and humans themselves—must be used. We demonstrate that 100 mg/L of GSPE stimulates peptide YY (PYY) release, but not glucagon-like peptide 1 (GLP-1) release in the human colon. We used a pig ex vivo system that differentiates between apical and basolateral intestinal sides to analyse how apical stimulation with GSPE and its pure compounds affects the gastrointestinal tract. In pigs, apical GSPE treatment stimulates the basolateral release of PYY in the duodenum and colon and that of GLP-1 in the ascending, but not the descending colon. In the duodenum, luminal stimulation with procyanidin dimer B2 increased PYY secretion, but not CCK secretion, while catechin monomers (catechin/epicatechin) significantly increased CCK release, but not PYY release. The differential effects of GSPE and its pure compounds on enterohormone release at the same intestinal segment suggest that they act through chemosensors located apically and unevenly distributed along the gastrointestinal tract.
DOI de l'article:10.3390/biom10060844
Enllaç font original:https://www.mdpi.com/2218-273X/10/6/844
Versió de l'article dipositat:info:eu-repo/semantics/publishedVersion
Accès a la llicència d'ús:https://creativecommons.org/licenses/by/3.0/es/
Departament:Bioquímica i Biotecnologia
URL Document de llicència:https://repositori.urv.cat/ca/proteccio-de-dades/
Àrees temàtiques:Química
Molecular biology
Materiais
General medicine
Farmacia
Ensino
Biochemistry & molecular biology
Biochemistry
Paraules clau:Vitis
Swine
Seeds
Pyy
Procyanidins
Proanthocyanidins
Proanthocyanidin
Plant extracts
Pig
Peptide yy
Metabolism
Intestine
Humans
Gut hormones
Grape seed extract
Glucagon-like peptide-1
Glucagon-like peptide 1
Glp-1
Ghrelin production
Gastrointestinal tract
Flavonoids
Cholecystokinin
Cells
Cck
Bitter
Animals
Absorption
pyy
glp-1
flavonoids
cck
Entitat:Universitat Rovira i Virgili
Data d'alta del registre:2024-10-19
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