Autor/s de la URV: | Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GONZALEZ QUILEN, CARLOS ALBERTO / Jorba Martin, Rosa Maria / Pinent Armengol, Montserrat / Terra Barbadora, Ximena |
Autor segons l'article: | Grau-Bove, Carme; Gonzalez-Quilen, Carlos; Terra, Ximena; Blay, M Teresa; Beltran-Debon, Raul; Jorba-Martin, Rosa; Espina, Beatriz; Pinent, Montserrat; Ardevol, Anna |
Adreça de correu electrònic de l'autor: | anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat montserrat.pinent@urv.cat rosamaria.jorba@urv.cat raul.beltran@urv.cat |
Identificador de l'autor: | 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0003-3307-4340 0000-0001-9691-1906 |
Any de publicació de la revista: | 2020 |
Tipus de publicació: | Journal Publications |
ISSN: | 2218273X |
Referència de l'ítem segons les normes APA: | Grau-Bove, Carme; Gonzalez-Quilen, Carlos; Terra, Ximena; Blay, M Teresa; Beltran-Debon, Raul; Jorba-Martin, Rosa; Espina, Beatriz; Pinent, Montserrat (2020). Effects of flavanols on enteroendocrine secretion. Biomolecules, 10(6), 1-14. DOI: 10.3390/biom10060844 |
Referència a l'article segons font original: | Biomolecules. 10 (6): 1-14 |
Resum: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Some beneficial effects of grape seed proanthocyanidin extract (GSPE) can be explained by the modulation of enterohormone secretion. As GSPE comprises a combination of different molecules, the pure compounds that cause these effects need to be elucidated. The enterohormones and chemoreceptors present in the gastrointestinal tract differ between species, so if humans are to gain beneficial effects, species closer to humans—and humans themselves—must be used. We demonstrate that 100 mg/L of GSPE stimulates peptide YY (PYY) release, but not glucagon-like peptide 1 (GLP-1) release in the human colon. We used a pig ex vivo system that differentiates between apical and basolateral intestinal sides to analyse how apical stimulation with GSPE and its pure compounds affects the gastrointestinal tract. In pigs, apical GSPE treatment stimulates the basolateral release of PYY in the duodenum and colon and that of GLP-1 in the ascending, but not the descending colon. In the duodenum, luminal stimulation with procyanidin dimer B2 increased PYY secretion, but not CCK secretion, while catechin monomers (catechin/epicatechin) significantly increased CCK release, but not PYY release. The differential effects of GSPE and its pure compounds on enterohormone release at the same intestinal segment suggest that they act through chemosensors located apically and unevenly distributed along the gastrointestinal tract. |
DOI de l'article: | 10.3390/biom10060844 |
Enllaç font original: | https://www.mdpi.com/2218-273X/10/6/844 |
Versió de l'article dipositat: | info:eu-repo/semantics/publishedVersion |
Accès a la llicència d'ús: | https://creativecommons.org/licenses/by/3.0/es/ |
Departament: | Bioquímica i Biotecnologia |
URL Document de llicència: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
Àrees temàtiques: | Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry |
Paraules clau: | Vitis Swine Seeds Pyy Procyanidins Proanthocyanidins Proanthocyanidin Plant extracts Pig Peptide yy Metabolism Intestine Humans Gut hormones Grape seed extract Glucagon-like peptide-1 Glucagon-like peptide 1 Glp-1 Ghrelin production Gastrointestinal tract Flavonoids Cholecystokinin Cells Cck Bitter Animals Absorption pyy glp-1 flavonoids cck |
Entitat: | Universitat Rovira i Virgili |
Data d'alta del registre: | 2024-10-19 |
Descripció: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Some beneficial effects of grape seed proanthocyanidin extract (GSPE) can be explained by the modulation of enterohormone secretion. As GSPE comprises a combination of different molecules, the pure compounds that cause these effects need to be elucidated. The enterohormones and chemoreceptors present in the gastrointestinal tract differ between species, so if humans are to gain beneficial effects, species closer to humans—and humans themselves—must be used. We demonstrate that 100 mg/L of GSPE stimulates peptide YY (PYY) release, but not glucagon-like peptide 1 (GLP-1) release in the human colon. We used a pig ex vivo system that differentiates between apical and basolateral intestinal sides to analyse how apical stimulation with GSPE and its pure compounds affects the gastrointestinal tract. In pigs, apical GSPE treatment stimulates the basolateral release of PYY in the duodenum and colon and that of GLP-1 in the ascending, but not the descending colon. In the duodenum, luminal stimulation with procyanidin dimer B2 increased PYY secretion, but not CCK secretion, while catechin monomers (catechin/epicatechin) significantly increased CCK release, but not PYY release. The differential effects of GSPE and its pure compounds on enterohormone release at the same intestinal segment suggest that they act through chemosensors located apically and unevenly distributed along the gastrointestinal tract. |
Tipus: | Journal Publications |
Coautor: | Universitat Rovira i Virgili |
Títol: | Effects of flavanols on enteroendocrine secretion |
Matèria: | Biochemistry,Biochemistry & Molecular Biology,Molecular Biology Vitis Swine Seeds Pyy Procyanidins Proanthocyanidins Proanthocyanidin Plant extracts Pig Peptide yy Metabolism Intestine Humans Gut hormones Grape seed extract Glucagon-like peptide-1 Glucagon-like peptide 1 Glp-1 Ghrelin production Gastrointestinal tract Flavonoids Cholecystokinin Cells Cck Bitter Animals Absorption pyy glp-1 flavonoids cck Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry |
Data: | 2020 |
Autor: | Grau-Bove, Carme Gonzalez-Quilen, Carlos Terra, Ximena Blay, M Teresa Beltran-Debon, Raul Jorba-Martin, Rosa Espina, Beatriz Pinent, Montserrat Ardevol, Anna |
Drets: | info:eu-repo/semantics/openAccess |
Cerca el teu registre a: |
Fitxer | Descripció | Format | |
---|---|---|---|
DocumentPrincipal | DocumentPrincipal | application/pdf |
© 2011 Universitat Rovira i Virgili