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Quantitative and topographic analysis by immunohistochemical expression of ghrelin gastric cells in patients with morbid obesity - imarina:7979989

Autor/es de la URV:Del Castillo Déjardin, Daniel / Mayayo Artal, Emilio Manuel / MOLINA LÓPEZ, ALICIA / Sabench Pereferrer, Fàtima
Autor según el artículo:David Parada D; Peña G KB; Vives M; Molina A; Mayayo E; Riu F; Sabench F; del Castillo D
Direcció de correo del autor:danieldel.castillo@urv.cat
emilio.mayayo@urv.cat
fatima.sabench@urv.cat
Identificador del autor:0000-0003-0456-3102
0000-0001-7024-7824
0000-0003-4485-3809
0000-0002-9262-8756
Año de publicación de la revista:2020
Tipo de publicación:Journal Publications
ISSN:11787007
Referencia de l'ítem segons les normes APA:David Parada D; Peña G KB; Vives M; Molina A; Mayayo E; Riu F; Sabench F; del Castillo D (2020). Quantitative and topographic analysis by immunohistochemical expression of ghrelin gastric cells in patients with morbid obesity. Diabetes Metabolic Syndrome And Obesity-Targets And Therapy, 13(), 2855-2864. DOI: 10.2147/DMSO.S260483
Referencia al articulo segun fuente origial:Diabetes Metabolic Syndrome And Obesity-Targets And Therapy. 13 2855-2864
Resumen:© 2020 Parada D et al. Purpose: The cellular distribution of ghrelin positive cells is not well defined. The aim of the study is to quantify and determine the distribution of ghrelin cells in gastric mucosa in patients with morbid obesity and relate this finding to gender, comorbidities, gastritis, and plasmatic levels of acyl and desacylghrelin before and after laparoscopic sleeve gastrectomy. Patient and Methods: We performed a study on 61 patients with BMI≥50 kg/m2 operated by laparoscopic sleeve gastrectomy. Three gastric regions were analyzed by histopathology and immunohistology. Blood sample was taken before surgery, and at 6 and 12 months post-surgery, to study the plasma levels of ghrelin isoforms. Results: Ghrelin cells are present in all regions of the gastric mucosa, with a greater number in the body and the fundus. Difference was found in the antrum between male and female patients (p=0.018). Patients with arterial hypertension also showed a lower level of cells in antrum (p<0.05). Acylghrelin levels after surgery were significantly lower (32.83+5.6 pg/mL to 10.09+11.8 pg/mL, p<0.05). Values of desacylghrelin tended to decrease but no significant variation was observed (207.4+39.3 pg/mL to 188.84+52.3 pg/mL). Conclusion: Our patients show ghrelin cells in all areas of the stomach. Gender, comorbid-ities, and gastritis are determinant on gastric ghrelin-producing cells distribution.
DOI del artículo:10.2147/DMSO.S260483
Enlace a la fuente original:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443401/
Versión del articulo depositado:info:eu-repo/semantics/publishedVersion
Acceso a la licencia de uso:https://creativecommons.org/licenses/by/3.0/es/
Departamento:Medicina i Cirurgia
Ciències Mèdiques Bàsiques
URL Documento de licencia:https://repositori.urv.cat/ca/proteccio-de-dades/
Áreas temáticas:Saúde coletiva
Pharmacology
Odontología
Nutrição
Medicina ii
Medicina i
Internal medicine
Interdisciplinar
Farmacia
Endocrinology & metabolism
Educação física
Ciências biológicas ii
Ciências biológicas i
Biotecnología
Palabras clave:Serum
Rats
Obesity
Laparoscopic surgery
Laparoscopic sleeve gastrectomy
Identification
Hormone
Histopathology
Helicobacter-pylori infection
Ghrelin
Gastric
Endocrine
Cells
Acylated peptide
laparoscopic surgery
ghrelin
gastric
cells
Entidad:Universitat Rovira i Virgili
Fecha de alta del registro:2023-02-23
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