Relationship Between Fatty Acid Binding Protein 4 and Liver Fat in Individuals at Increased Cardiometabolic Risk

Rodríguez-Calvo R; Moreno-Vedia J; Girona J; Ibarretxe D; Martínez-Micaelo N; Merino J; Plana N; Masana L

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Relationship Between Fatty Acid Binding Protein 4 and Liver Fat in Individuals at Increased Cardiometabolic Risk - imarina:9242341

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https://hdl.handle.net/20.500.11797/imarina9242341

Autor/es de la URV:	Girona Tell, Josefa / Ibarretxe Gerediaga, Daiana / Martínez Micaelo, Nieves Beatriz / Masana Marín, Luis / MERINO RIBAS, JORDI / Moreno Vedia, Juan / Plana Gil, Núria / Rodríguez Calvo, Ricardo
Autor según el artículo:	Rodríguez-Calvo R; Moreno-Vedia J; Girona J; Ibarretxe D; Martínez-Micaelo N; Merino J; Plana N; Masana L
Direcció de correo del autor:	daiana.ibarretxe@urv.cat neus.martinez@urv.cat luis.masana@urv.cat josefa.girona@urv.cat ricardo.rodriguez@urv.cat josefa.girona@urv.cat juan.moreno@estudiants.urv.cat juan.moreno@estudiants.urv.cat
Identificador del autor:	0000-0002-0789-4954 0000-0002-6267-8779 0000-0002-6267-8779 0000-0002-2673-3822 0000-0002-2673-3822
Año de publicación de la revista:	2021
Tipo de publicación:	Journal Publications
Referencia de l'ítem segons les normes APA:	Rodríguez-Calvo R; Moreno-Vedia J; Girona J; Ibarretxe D; Martínez-Micaelo N; Merino J; Plana N; Masana L (2021). Relationship Between Fatty Acid Binding Protein 4 and Liver Fat in Individuals at Increased Cardiometabolic Risk. Frontiers In Physiology, 12(), -. DOI: 10.3389/fphys.2021.781789
Referencia al articulo segun fuente origial:	Frontiers In Physiology. 12
Resumen:	Background: Liver steatosis is considered the onset of the non-alcoholic fatty liver disease (NAFLD), a major public health challenge. Nevertheless, NAFLD detection and diagnosis remain a difficult task. Fatty acid binding protein 4 (FABP4) has been proposed as potential biomarker for the ectopic fat accumulation in non-adipose tissues, although its role reflecting liver steatosis in metabolic patients is not fully explored. The aim of this study was to assess the relationship between FABP4 and the fatty liver index (FLI) in metabolic patients and to evaluate its potential role in the fatty liver disease. Methods: A cross-sectional study involving 389 participants at increased cardiometabolic risk was performed. FLI was calculated in order to assess liver fatty disease and a FLI ? 60 was considered to define liver steatosis. The serum FABP4 levels were assessed by using a sandwich enzyme-linked immunosorbent assay. Multivariable regression models were used to examine the associations of FABP4 with fatty liver after adjusting for demographic and clinical characteristics. Results: Both, FLI and serum FABP4 levels were upregulated in diabetic, obese, and metabolic syndrome patients. Serum FABP4 levels were higher in individuals with liver steatosis. Serum FABP4 were robustly associated with FLI in metabolic patients in both linear and logistic regression analyses. Conclusion: Our findings show that the serum FABP4 is associated to liver steatosis in metabolic patients. Copyright © 2021 Rodríguez-Calvo, Moreno-Vedia, Girona, Ibarretxe, Martínez-Micaelo, Merino, Plana and Masana.
DOI del artículo:	10.3389/fphys.2021.781789
Enlace a la fuente original:	https://www.frontiersin.org/articles/10.3389/fphys.2021.781789/full?utm_source=dlvr.it&utm_medium=twitter
Versión del articulo depositado:	info:eu-repo/semantics/publishedVersion
Acceso a la licencia de uso:	https://creativecommons.org/licenses/by/3.0/es/
Departamento:	Medicina i Cirurgia Ciències Mèdiques Bàsiques
URL Documento de licencia:	https://repositori.urv.cat/ca/proteccio-de-dades/
Áreas temáticas:	Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Physiology (medical) Physiology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Ensino Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
Palabras clave:	Nafld (non-alcoholic fatty liver disease) Metabolic patients Fli (fatty liver index) Fatty liver Fabp4 (fatty acid binding protein 4) External validation nafld (non-alcoholic fatty liver disease) metabolic patients indicator index fli (fatty liver index) fatty liver etiology disease cohort
Entidad:	Universitat Rovira i Virgili
Fecha de alta del registro:	2024-07-27

Descripción:	Background: Liver steatosis is considered the onset of the non-alcoholic fatty liver disease (NAFLD), a major public health challenge. Nevertheless, NAFLD detection and diagnosis remain a difficult task. Fatty acid binding protein 4 (FABP4) has been proposed as potential biomarker for the ectopic fat accumulation in non-adipose tissues, although its role reflecting liver steatosis in metabolic patients is not fully explored. The aim of this study was to assess the relationship between FABP4 and the fatty liver index (FLI) in metabolic patients and to evaluate its potential role in the fatty liver disease. Methods: A cross-sectional study involving 389 participants at increased cardiometabolic risk was performed. FLI was calculated in order to assess liver fatty disease and a FLI ? 60 was considered to define liver steatosis. The serum FABP4 levels were assessed by using a sandwich enzyme-linked immunosorbent assay. Multivariable regression models were used to examine the associations of FABP4 with fatty liver after adjusting for demographic and clinical characteristics. Results: Both, FLI and serum FABP4 levels were upregulated in diabetic, obese, and metabolic syndrome patients. Serum FABP4 levels were higher in individuals with liver steatosis. Serum FABP4 were robustly associated with FLI in metabolic patients in both linear and logistic regression analyses. Conclusion: Our findings show that the serum FABP4 is associated to liver steatosis in metabolic patients. Copyright © 2021 Rodríguez-Calvo, Moreno-Vedia, Girona, Ibarretxe, Martínez-Micaelo, Merino, Plana and Masana.
Tipo:	Journal Publications
Coautor:	Universitat Rovira i Virgili
Títol:	Relationship Between Fatty Acid Binding Protein 4 and Liver Fat in Individuals at Increased Cardiometabolic Risk
Materia:	Physiology,Physiology (Medical) Nafld (non-alcoholic fatty liver disease) Metabolic patients Fli (fatty liver index) Fatty liver Fabp4 (fatty acid binding protein 4) External validation nafld (non-alcoholic fatty liver disease) metabolic patients indicator index fli (fatty liver index) fatty liver etiology disease cohort Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Physiology (medical) Physiology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Ensino Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
Fecha:	2021
Autor:	Rodríguez-Calvo R Moreno-Vedia J Girona J Ibarretxe D Martínez-Micaelo N Merino J Plana N Masana L
Derechos:	info:eu-repo/semantics/openAccess

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