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SALDI-MS and SERS Multimodal Imaging: One Nanostructured Substrate to Rule Them Both - imarina:9245547

Autor/es de la URV:Baquer Gómez, Gerard Sergi / Correig Blanchar, Francesc Xavier / Garcia-Altares Pérez, Maria / Ràfols Soler, Pere / Ramírez Falo, José Luis
Autor según el artículo:Iakab, Stefania-Alexandra; Baquer, Gerard; Lafuente, Marta; Pina, Maria Pilar; Ramirez, Jose Luis; Rafols, Pere; Correig-Blanchar, Xavier; Garcia-Altares, Maria
Direcció de correo del autor:maria.garcia-altares@urv.cat
pere.rafols@urv.cat
gerard.baquer@estudiants.urv.cat
gerard.baquer@estudiants.urv.cat
joseluis.ramirez@urv.cat
xavier.correig@urv.cat
Identificador del autor:0000-0002-9240-4058
0000-0002-4433-4972
0000-0002-4433-4972
0000-0001-8231-4019
0000-0002-6902-3054
Año de publicación de la revista:2022
Tipo de publicación:Journal Publications
Referencia de l'ítem segons les normes APA:Iakab, Stefania-Alexandra; Baquer, Gerard; Lafuente, Marta; Pina, Maria Pilar; Ramirez, Jose Luis; Rafols, Pere; Correig-Blanchar, Xavier; Garcia-Alta (2022). SALDI-MS and SERS Multimodal Imaging: One Nanostructured Substrate to Rule Them Both. Analytical Chemistry, 94(6), 2785-2793. DOI: 10.1021/acs.analchem.1c04118
Referencia al articulo segun fuente origial:Analytical Chemistry. 94 (6): 2785-2793
Resumen:Imaging techniques based on mass spectrometry or spectroscopy methods inform in situ about the chemical composition of biological tissues or organisms, but they are sometimes limited by their specificity, sensitivity, or spatial resolution. Multimodal imaging addresses these limitations by combining several imaging modalities; however, measuring the same sample with the same preparation using multiple imaging techniques is still uncommon due to the incompatibility between substrates, sample preparation protocols, and data formats. We present a multimodal imaging approach that employs a gold-coated nanostructured silicon substrate to couple surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) and surface-enhanced Raman spectroscopy (SERS). Our approach integrates both imaging modalities by using the same substrate, sample preparation, and data analysis software on the same sample, allowing the coregistration of both images. We transferred molecules from clean fingertips and fingertips covered with plasticine modeling clay onto our nanostructure and analyzed their chemical composition and distribution by SALDI-MS and SERS. Multimodal analysis located the traces of plasticine on fingermarks and provided chemical information on the composition of the clay. Our multimodal approach effectively combines the advantages of mass spectrometry and vibrational spectroscopy with the signal enhancing abilities of our nanostructured substrate.
DOI del artículo:10.1021/acs.analchem.1c04118
Enlace a la fuente original:https://pubs.acs.org/doi/10.1021/acs.analchem.1c04118
Versión del articulo depositado:info:eu-repo/semantics/publishedVersion
Acceso a la licencia de uso:https://creativecommons.org/licenses/by/3.0/es/
Departamento:Enginyeria Electrònica, Elèctrica i Automàtica
URL Documento de licencia:https://repositori.urv.cat/ca/proteccio-de-dades/
Áreas temáticas:Química
Medicina ii
Medicina i
Materiais
Interdisciplinar
Geociências
General medicine
Farmacia
Ensino
Engenharias iv
Engenharias iii
Engenharias ii
Enfermagem
Ciências biológicas iii
Ciências biológicas ii
Ciências biológicas i
Ciências ambientais
Ciências agrárias i
Ciência de alimentos
Ciência da computação
Chemistry, analytical
Biotecnología
Biodiversidade
Astronomia / física
Analytical chemistry
Palabras clave:Spectrum analysis
Spectrometry, mass, matrix-assisted laser desorption-ionization
Silicon
Nanostructures
Gold
Desorption/ionization mass-spectrometry
workflow
vibrational spectroscopy
scattering
raman-spectroscopy
maldi-tof
images
database
breast-cancer
Entidad:Universitat Rovira i Virgili
Fecha de alta del registro:2025-01-08
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