Autor/s de la URV: | Arola Arnal, Anna / Arreaza Gil, Verónica / Ávila Román, Francisco Javier / Escobar Martínez, Ivan / Muguerza Marquínez, Maria Begoña / Suárez Recio, Manuel / Torres Fuentes, Cristina |
Autor segons l'article: | Arreaza-Gil, Veronica; Avila-Roman, Javier; Escobar-Martinez, Ivan; Muguerza, Begona; Suarez, Manuel; Arola-Arnal, Anna; Torres-Fuentes, Cristina |
Adreça de correu electrònic de l'autor: | franciscojavier.avila@urv.cat ivan.escobar@estudiants.urv.cat veronica.arreaza@urv.cat veronica.arreaza@urv.cat veronica.arreaza@urv.cat manuel.suarez@urv.cat anna.arola@urv.cat begona.muguerza@urv.cat cristina.torres@urv.cat |
Identificador de l'autor: | 0000-0001-9766-8178 0000-0002-8301-2095 0000-0002-8301-2095 0000-0002-8301-2095 0000-0003-0122-8253 0000-0001-6529-1345 0000-0001-7384-8588 0000-0002-2917-6910 |
Any de publicació de la revista: | 2023 |
Tipus de publicació: | Journal Publications |
Referència de l'ítem segons les normes APA: | Arreaza-Gil, Veronica; Avila-Roman, Javier; Escobar-Martinez, Ivan; Muguerza, Begona; Suarez, Manuel; Arola-Arnal, Anna; Torres-Fuentes, Cristina (2023). Photoperiod Conditions Modulate Serum Oxylipins Levels in Healthy and Obese Rats: Impact of Proanthocyanidins and Gut Microbiota. Nutrients, 15(3), 707-. DOI: 10.3390/nu15030707 |
Referència a l'article segons font original: | Nutrients. 15 (3): 707- |
Resum: | Seasonal rhythms are emerging as a key factor influencing gut microbiota and bioactive compounds functionality as well as several physiological processes such as inflammation. In this regard, their impact on the modulation of oxylipins (OXLs), which are important lipid mediators of inflammatory processes, has not been investigated yet. Hence, we aimed to investigate the effects of photoperiods on OXLs metabolites in healthy and obesogenic conditions. Moreover, we evaluated if the impact of proanthocyanidins and gut microbiota on OXLs metabolism is influenced by photoperiod in obesity. To this purpose, Fischer 344 rats were housed under different photoperiod conditions (L6: 6 h light, L12: 12 h light or L18:18 h light) and fed either a standard chow diet (STD) or a cafeteria diet (CAF) for 9 weeks. During the last 4 weeks, obese rats were daily administered with an antibiotic cocktail (ABX), an oral dose of a grape seed proanthocyanidin extract (GSPE), or with their combination. CAF feeding and ABX treatment affected OXLs in a photoperiod dependent-manner. GSPE significantly altered prostaglandin E2 (PGE2) levels, only under L6 and mitigated ABX-mediated effects only under L18. In conclusion, photoperiods affect OXLs levels influenced by gut microbiota. This is the first time that the effects of photoperiod on OXLs metabolites have been demonstrated. |
DOI de l'article: | 10.3390/nu15030707 |
Enllaç font original: | https://www.mdpi.com/2072-6643/15/3/707 |
Versió de l'article dipositat: | info:eu-repo/semantics/publishedVersion |
Accès a la llicència d'ús: | https://creativecommons.org/licenses/by/3.0/es/ |
Departament: | Bioquímica i Biotecnologia |
URL Document de llicència: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
Àrees temàtiques: | Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología |
Paraules clau: | Seasonal-variation Resolvins Rats, wistar Rats, inbred f344 Rats Proanthocyanidins Photoperiod Oxylipins Obesity Gspe Grape seed extract Gastrointestinal microbiome Cafeteria diet Biological rhythms Animals weight resolvins profiles obesity metabolism mediators inflammation gspe clock cafeteria diet acid |
Entitat: | Universitat Rovira i Virgili |
Data d'alta del registre: | 2024-12-28 |
Descripció: | Seasonal rhythms are emerging as a key factor influencing gut microbiota and bioactive compounds functionality as well as several physiological processes such as inflammation. In this regard, their impact on the modulation of oxylipins (OXLs), which are important lipid mediators of inflammatory processes, has not been investigated yet. Hence, we aimed to investigate the effects of photoperiods on OXLs metabolites in healthy and obesogenic conditions. Moreover, we evaluated if the impact of proanthocyanidins and gut microbiota on OXLs metabolism is influenced by photoperiod in obesity. To this purpose, Fischer 344 rats were housed under different photoperiod conditions (L6: 6 h light, L12: 12 h light or L18:18 h light) and fed either a standard chow diet (STD) or a cafeteria diet (CAF) for 9 weeks. During the last 4 weeks, obese rats were daily administered with an antibiotic cocktail (ABX), an oral dose of a grape seed proanthocyanidin extract (GSPE), or with their combination. CAF feeding and ABX treatment affected OXLs in a photoperiod dependent-manner. GSPE significantly altered prostaglandin E2 (PGE2) levels, only under L6 and mitigated ABX-mediated effects only under L18. In conclusion, photoperiods affect OXLs levels influenced by gut microbiota. This is the first time that the effects of photoperiod on OXLs metabolites have been demonstrated. |
Tipus: | Journal Publications |
Coautor: | Universitat Rovira i Virgili |
Títol: | Photoperiod Conditions Modulate Serum Oxylipins Levels in Healthy and Obese Rats: Impact of Proanthocyanidins and Gut Microbiota |
Matèria: | Food Science,Nutrition & Dietetics,Nutrition and Dietetics Seasonal-variation Resolvins Rats, wistar Rats, inbred f344 Rats Proanthocyanidins Photoperiod Oxylipins Obesity Gspe Grape seed extract Gastrointestinal microbiome Cafeteria diet Biological rhythms Animals weight resolvins profiles obesity metabolism mediators inflammation gspe clock cafeteria diet acid Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología |
Data: | 2023 |
Autor: | Arreaza-Gil, Veronica Avila-Roman, Javier Escobar-Martinez, Ivan Muguerza, Begona Suarez, Manuel Arola-Arnal, Anna Torres-Fuentes, Cristina |
Drets: | info:eu-repo/semantics/openAccess |
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