Repositori institucional URV
| URV's Author/s: | BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia |
| Author, as appears in the article.: | Biosca-Brull, J; Guardia-Escote, L; Basaure, P; Cabré, M; Blanco, J; Pérez-Fernández, C; Sánchez-Santed, F; Domingo, JL; Colomina, MT |
| Author's mail: | jordi.blanco@urv.cat maria.cabre@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat joseluis.domingo@urv.cat mariateresa.colomina@urv.cat |
| Author identifier: | 0000-0001-8016-0984 0000-0003-4124-8603 0000-0001-6647-9470 0000-0002-5619-4874 |
| Journal publication year: | 2023 |
| Publication Type: | Journal Publications |
| APA: | Biosca-Brull, J; Guardia-Escote, L; Basaure, P; Cabré, M; Blanco, J; Pérez-Fernández, C; Sánchez-Santed, F; Domingo, JL; Colomina, MT (2023). Exposure to chlorpyrifos during pregnancy differentially affects social behavior and GABA signaling elements in an APOE- and sex-dependent manner in a transgenic mouse model. Environmental Research, 224(), 115461-115461. DOI: 10.1016/j.envres.2023.115461 |
| Papper original source: | Environmental Research. 224 115461-115461 |
| Abstract: | The massive use of chlorpyrifos (CPF) has been associated with an increased prevalence of neurodevelopmental disorders. Some previous studies have shown that prenatal, but not postnatal, CPF exposure causes social behavior deficits in mice depending on sex while others have found that in transgenic mice models carrying the human apolipoprotein E (APOE) ε3 and ε4 allele confer different vulnerabilities to either behavioral or metabolic disorders after CPF exposure. This study aims to evaluate, in both sexes, how prenatal CPF exposure and APOE genotype impact on social behavior and its relation to changes in GABAergic and glutamatergic systems. For this purpose, apoE3 and apoE4 transgenic mice were exposed through the diet to 0 or 1 mg/kg/day of CPF, between gestational day 12 and 18. A three-chamber test was used to assess social behavior on postnatal day (PND) 45. Then, mice were sacrificed, and hippocampal samples were analyzed to study the gene expression of GABAergic and glutamatergic elements. Results showed that prenatal exposure to CPF impaired social novelty preference and increased the expression of GABA-A α1 subunit in females of both genotypes. In addition, the expression of GAD1, the ionic cotransporter KCC2 and the GABA-A α2 and α5 subunits were increased in apoE3 mice, whereas CPF treatment only accentuated the expression of GAD1 and KCC2. Nevertheless, future research is needed to evaluate whether the influences detected in the GABAergic system are present and functionally relevant in adults and old mice.Copyright © 2023. Published by Elsevier Inc. |
| Article's DOI: | 10.1016/j.envres.2023.115461 |
| Link to the original source: | https://www.sciencedirect.com/science/article/pii/S0013935123002530?via%3Dihub |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Psicologia Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física |
| Keywords: | Social behavior Organophosphorus pesticide-residues Glutamate Gaba Chlorpyrifos Autism Apoe valproic acid social behavior receptor subunit insecticide chlorpyrifos glutamate gaba female mice expression developmental neurotoxicity brain maturation autism apolipoprotein e4 apoe animal-model |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-08-03 |
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