Repositori institucional URV
| URV's Author/s: | Girona Tell, Josefa / Guardiola Guionnet, Montserrat / Rehues Masip, Pere / Ribalta Vives, Josep |
| Author, as appears in the article.: | Guardiola M; Rehues P; Amigó N; Arrieta F; Botana M; Gimeno-Orna JA; Girona J; Martínez-Montoro JI; Ortega E; Pérez-Pérez A; Sánchez-Margalet V; Pedro-Botet J; Ribalta J |
| Author's mail: | pere.rehues@urv.cat josefa.girona@urv.cat pere.rehues@urv.cat josefa.girona@urv.cat montse.guardiola@urv.cat josep.ribalta@urv.cat |
| Author identifier: | 0000-0002-6267-8779 0000-0002-6267-8779 0000-0002-9696-7384 0000-0002-8879-4719 |
| Journal publication year: | 2024 |
| Publication Type: | Journal Publications |
| APA: | Guardiola M; Rehues P; Amigó N; Arrieta F; Botana M; Gimeno-Orna JA; Girona J; Martínez-Montoro JI; Ortega E; Pérez-Pérez A; Sánchez-Margalet V; Pedro (2024). Increasing the complexity of lipoprotein characterization for cardiovascular risk in type 2 diabetes. European Journal Of Clinical Investigation, (), e14214-e14214. DOI: 10.1111/eci.14214 |
| Papper original source: | European Journal Of Clinical Investigation. e14214-e14214 |
| Abstract: | The burden of cardiovascular disease is particularly high among individuals with diabetes, even when LDL cholesterol is normal or within the therapeutic target. Despite this, cholesterol accumulates in their arteries, in part, due to persistent atherogenic dyslipidaemia characterized by elevated triglycerides, remnant cholesterol, smaller LDL particles and reduced HDL cholesterol. The causal link between dyslipidaemia and atherosclerosis in T2DM is complex, and our contention is that a deeper understanding of lipoprotein composition and functionality, the vehicle that delivers cholesterol to the artery, will provide insight for improving our understanding of the hidden cardiovascular risk of diabetes. This narrative review covers three levels of complexity in lipoprotein characterization: 1-the information provided by routine clinical biochemistry, 2-advanced nuclear magnetic resonance (NMR)-based lipoprotein profiling and 3-the identification of minor components or physical properties of lipoproteins that can help explain arterial accumulation in individuals with normal LDLc levels, which is typically the case in individuals with T2DM. This document highlights the importance of incorporating these three layers of lipoprotein-related information into population-based studies on ASCVD in T2DM. Such an attempt should inevitably run in parallel with biotechnological solutions that allow large-scale determination of these sets of methodologically diverse parameters.© 2024 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. |
| Article's DOI: | 10.1111/eci.14214 |
| Link to the original source: | https://onlinelibrary.wiley.com/doi/10.1111/eci.14214 |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Medicina i Cirurgia Ciències Mèdiques Bàsiques |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Saúde coletiva Odontología Nutrição Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry |
| Keywords: | Nmr Lps Lipoprotein Diabetes Cardiovascular risk Apoc‐iii Apoc-iii |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-09-21 |
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| DocumentPrincipal | DocumentPrincipal | application/pdf |
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