Repositori institucional URV
Español Català English
TITLE:
Effect of 1-year lifestyle intervention with energy-reduced Mediterranean diet and physical activity promotion on the gut metabolome and microbiota: a randomized clinical trial - imarina:9373512

URV's Author/s:Atzeni, Alessandro / Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / HERNÁNDEZ CACHO, ADRIÁN / Martínez Rodríguez, María Ángeles / MARTÍNEZ VERA, MARÍA ASUNCIÓN / Salas Salvadó, Jorge
Author, as appears in the article.:Garcia-Gavilan, Jesis F; Atzeni, Alessandro; Babio, Nancy; Liang, Liming; Belzer, Clara; Vioque, Jesus; Corella, Dolores; Fito, Montserrat; Vidal, Josep; Moreno-Indias, Isabel; Torres-Collado, Laura; Coltell, Oscar; Toledo, Estefania; Clish, Clary; Hernando, Javier; Yun, Huan; Hernandez-Cacho, Adrian; Jeanfavre, Sarah; Dennis, Courtney; Gomez-Perez, Ana M; Martinez, Maria Angeles; Ruiz-Canela, Miguel; Tinahones, Francisco J; Hu, Frank B; Salas-Salvado, Jordi
Author's mail:jesusfrancisco.garcia@urv.cat
adrian.hernandez@urv.cat
alessandro.atzeni@urv.cat
mangeles.martinez@urv.cat
jesusfrancisco.garcia@urv.cat
alessandro.atzeni@urv.cat
jordi.salas@urv.cat
nancy.babio@urv.cat
Author identifier:0000-0002-1804-8606
0000-0001-8595-3772
0000-0002-1804-8606
0000-0003-2700-7459
0000-0003-3527-5277
Journal publication year:2024
Publication Type:Journal Publications
APA:Garcia-Gavilan, Jesis F; Atzeni, Alessandro; Babio, Nancy; Liang, Liming; Belzer, Clara; Vioque, Jesus; Corella, Dolores; Fito, Montserrat; Vidal, Jos (2024). Effect of 1-year lifestyle intervention with energy-reduced Mediterranean diet and physical activity promotion on the gut metabolome and microbiota: a randomized clinical trial. American Journal Of Clinical Nutrition, 119(5), 1143-1154. DOI: 10.1016/j.ajcnut.2024.02.021
Papper original source:American Journal Of Clinical Nutrition. 119 (5): 1143-1154
Abstract:Background: The health bene fi ts of the Mediterranean diet (MedDiet) have been linked to the presence of bene fi cial gut microbes and related metabolites. However, its impact on the fecal metabolome remains poorly understood. Objectives: Our goal was to investigate the weight-loss effects of a 1-y lifestyle intervention based on an energy-reduced MedDiet coupled with physical activity (intervention group), compared with an ad libitum MedDiet (control group), on fecal metabolites, fecal microbiota, and their potential association with cardiovascular disease risk factors. Methods: A total of 400 participants (200 from each study group), aged 55 - 75 y, and at high cardiovascular disease risk, were included. Dietary and lifestyle information, anthropometric measurements, blood biochemical parameters, and stool samples were collected at baseline and after 1 y of followup. Liquid chromatography-tandem mass spectrometry was used to pro fi le endogenous fecal metabolites, and 16S amplicon sequencing was employed to pro fi le the fecal microbiota. Results: Compared with the control group, the intervention group exhibited greater weight loss and improvement in various cardiovascular disease risk factors. We identi fi ed intervention effects on 4 stool metabolites and subnetworks primarily composed of bile acids, ceramides, and sphingosines, fatty acids, carnitines, nucleotides, and metabolites of purine and the Krebs cycle. Some of these were associated with changes in several cardiovascular disease risk factors. In addition, we observed a reduction in the abundance of the genera Eubacterium hallii group and Dorea , and an increase in alpha diversity in the intervention group after 1 y of follow-up. Changes in the intervention -related microbiota pro fi les were also associated with alterations in different fecal metabolite subnetworks and some cardiovascular disease risk factors. Conclusions: An intervention based on an energy -reduced MedDiet and physical activity promotion, compared with an ad libitum MedDiet, was associated with improvements in cardiometabolic risk factors, potentially through modulation of the fecal microbiota and metabolome. This trial was registered at https://www.isrctn.com/ as ISRCTN89898870 (https://doi.org/10.1186/ISRCTN89898870).
Article's DOI:10.1016/j.ajcnut.2024.02.021
Link to the original source:https://www.sciencedirect.com/science/article/pii/S0002916524001679?via%3Dihub
Papper version:info:eu-repo/semantics/publishedVersion
licence for use:https://creativecommons.org/licenses/by/3.0/es/
Department:Bioquímica i Biotecnologia
Licence document URL:https://repositori.urv.cat/ca/proteccio-de-dades/
Thematic Areas:Serviço social
Saúde coletiva
Odontología
Nutrition and dietetics
Nutrition & dietetics
Nutrição
Medicine (miscellaneous)
Medicina iii
Medicina ii
Medicina i
General medicine
Enfermagem
Educação física
Ciências biológicas ii
Ciência de alimentos
Biotecnología
Keywords:Sphingolipids
Obesity
Metabolic syndrome
Mediterranean diet
Lifestyle intervention
Insulin-resistance
Glucos
Fecal microbiota
Fecal metabolome
Fecal metabolom
Cholesterol
Cardiovascular disease risk factor
Cardiocascular risk factor
Bile-acid
Adherence
Entity:Universitat Rovira i Virgili
Record's date:2024-08-03
Search your record at:

Available files
FileDescriptionFormat
DocumentPrincipalDocumentPrincipalapplication/pdf

Information

© 2011 Universitat Rovira i Virgili