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TITLE:
Involvement of extracellular vesicle-encapsulated miRNAs in human reproductive disorders: a systematic review. - imarina:9378108

URV's Author/s:Salas Huetos, Albert
Author, as appears in the article.:Barranco I; Salas-Huetos A; Berlanga A; Spinaci M; Yeste M; Ribas-Maynou J
Author's mail:albert.salas@urv.cat
Author identifier:0000-0001-5914-6862
Journal publication year:2022
Publication Type:Journal Publications
APA:Barranco I; Salas-Huetos A; Berlanga A; Spinaci M; Yeste M; Ribas-Maynou J (2022). Involvement of extracellular vesicle-encapsulated miRNAs in human reproductive disorders: a systematic review.. Reproduction Fertility And Development, 34(11), 751-775. DOI: 10.1071/RD21301
Papper original source:Reproduction Fertility And Development. 34 (11): 751-775
Abstract:In recent years, extracellular vesicles (EVs) have emerged as essential players in cell-to-cell communication, particularly having an active regulating role in biological systems. Because reproductive-associated processes are not exempt of this communication, multiple studies have been devoted to this realm, focusing on gamete maturation, embryo implantation or fetal development. The aim of the present review was to comprehensively and systematically collect evidence about the function of the microRNA (miRNA) encapsulated in EVs isolated from different reproductive tissues or fluids in reproductive-related diseases. Following PRISMA guidelines, we conducted a systematic search of the literature published in MEDLINE-PubMed until the end of February 2021. After selection, 32 studies were included in the qualitative review comparing the miRNA expression profile in EVs between different pathological disorders. Most reports showed the potential of the miRNAs carried by EVs to be used as putative biomarkers of reproductive disorders, including pregnancy affections, disease progression and quality of preimplantation embryos. The most relevant miRNAs were found to be highly heterogeneous among studies, with some conflicting results. Further research is thus warranted to address whether cofounding factors, such as the methods to isolate EVs and miRNAs, the subset of EVs, the criteria of patient selection, the timing of sample retrieval, or any other factor, may explain the inconsistencies between studies.
Article's DOI:10.1071/RD21301
Link to the original source:https://www.publish.csiro.au/RD/RD21301
Papper version:info:eu-repo/semantics/acceptedVersion
licence for use:https://creativecommons.org/licenses/by/3.0/es/
Department:Ciències Mèdiques Bàsiques
Licence document URL:https://repositori.urv.cat/ca/proteccio-de-dades/
Thematic Areas:Animal science and zoology
Biodiversidade
Biotechnology
Biotecnología
Ciências agrárias i
Ciências ambientais
Ciências biológicas i
Ciências biológicas ii
Ciências biológicas iii
Developmental biology
Endocrinology
Farmacia
Genetics
Interdisciplinar
Medicina i
Medicina ii
Medicina iii
Medicina veterinaria
Medicine (all)
Molecular biology
Odontología
Psicología
Química
Reproductive biology
Reproductive medicine
Zoology
Zootecnia / recursos pesqueiros
Keywords:Blastocyst
Cell communication
Embryo implantation
Extracellular vesicles
Female
Humans
Micrornas
Pregnancy
Entity:Universitat Rovira i Virgili
Record's date:2024-07-20
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