Repositori institucional URV
| Autor/s de la URV: | Bernús Pérez, Miguel / Boutureira Martín, Omar |
| Autor segons l'article: | Mazzarella, Daniele; Stanic, Jelena; Bernus, Miguel; Mehdi, Arad Seyed; Henderson, Cassandra J; Boutureira, Omar; Noel, Timothy |
| Adreça de correu electrònic de l'autor: | miguel.bernus@urv.cat omar.boutureira@urv.cat |
| Identificador de l'autor: | 0000-0003-0302-0720 0000-0002-0768-8309 |
| Any de publicació de la revista: | 2024 |
| Tipus de publicació: | Journal Publications |
| Referència de l'ítem segons les normes APA: | Mazzarella, Daniele; Stanic, Jelena; Bernus, Miguel; Mehdi, Arad Seyed; Henderson, Cassandra J; Boutureira, Omar; Noel, Timothy (2024). In-Flow Generation of Thionyl Fluoride (SOF2) Enables the Rapid and Efficient Synthesis of Acyl Fluorides from Carboxylic Acids. Jacs Au, 4(8), 2989-2994. DOI: 10.1021/jacsau.4c00318 |
| Referència a l'article segons font original: | Jacs Au. 4 (8): 2989-2994 |
| Resum: | Herein, we report an approach for generating thionyl fluoride (SOF2) from the commodity chemicals thionyl chloride (SOCl2) and potassium fluoride (KF). The methodology relies on a microfluidic device that can efficiently produce and dose this toxic gaseous reagent under extremely mild and safe conditions. Subsequently, the in situ-generated thionyl fluoride is reacted with an array of structurally and electronically differing carboxylic acids, leading to the direct and efficient synthesis of highly sought-after acyl fluorides. Importantly, our investigation also highlights the inherent modularity of this flow-based platform. We demonstrate the adaptability of this approach by not only synthesizing acyl fluorides but also directly converting carboxylic acids into a diverse array of valuable compounds such as esters, thioesters, amides, and ketones. This versatility showcases the potential of this approach for a wide range of synthetic applications, underscoring its significance in the realm of chemical synthesis. |
| DOI de l'article: | 10.1021/jacsau.4c00318 |
| Enllaç font original: | https://pubs.acs.org/doi/full/10.1021/jacsau.4c00318 |
| Versió de l'article dipositat: | info:eu-repo/semantics/publishedVersion |
| Accès a la llicència d'ús: | https://creativecommons.org/licenses/by/3.0/es/ |
| Departament: | Química Analítica i Química Orgànica |
| URL Document de llicència: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Àrees temàtiques: | Physical and theoretical chemistry Organic chemistry Chemistry, multidisciplinary Chemistry (miscellaneous) Analytical chemistry |
| Paraules clau: | Tetrafluoride Technology Surrogate Sulfur-dioxide Spectrum deoxofluorinating agent Reagent On-demand synthesis Multistep synthesis Multistep synthesi Gaseousreagents Gaseous reagents Fluorine chemistry Fluorination Flow chemistry Chemistry Carbonylation Bis(2-methoxyethyl)aminosulfur trifluoride |
| Entitat: | Universitat Rovira i Virgili |
| Data d'alta del registre: | 2024-11-30 |
| Cerca el teu registre a: |   |
| Fitxer | Descripció | Format | |
|---|---|---|---|
| DocumentPrincipal | DocumentPrincipal | application/pdf |
© 2011 Universitat Rovira i Virgili