Repositori institucional URV
| URV's Author/s: | García Gavilán, Jesús Francisco / Salas Salvadó, Jorge |
| Author, as appears in the article.: | Hernandez-Cacho, Adrian; Garcia-Gavilan, Jesus F; Atzeni, Alessandro; Konstanti, Prokopis; Belzer, Clara; Vioque, Jesus; Corella, Dolores; Fito, Montserrat; Vidal, Josep; Mela, Virginia; Liang, Liming; Torres-Collado, Laura; Coltell, Oscar; Babio, Nancy; Clish, Clary; Hernando-Redondo, Javier; Martinez-Gonzalez, Miguel A; Wang, Fenglei; Moreno-Indias, Isabel; Ni, Jiaqi; Dennis, Courtney; Ruiz-Canela, Miguel; Tinahones, Francisco J; Hu, Frank B; Salas-Salvado, Jordi |
| Author's mail: | jesusfrancisco.garcia@urv.cat jesusfrancisco.garcia@urv.cat jordi.salas@urv.cat |
| Author identifier: | 0000-0002-3707-5255 0000-0002-3707-5255 0000-0003-2700-7459 |
| Journal publication year: | 2025 |
| Publication Type: | Journal Publications |
| Paper original source: | Npj Biofilms And Microbiomes. 11 (1): 68- |
| Abstract: | The gut microbiota plays a potential role in the pathophysiology of depression through the gut-brain axis. This cross-sectional study in 400 participants from the PREDIMED-Plus study investigates the interplay between gut microbiota and depression using a multi-omics approach. Depression was defined as antidepressant use or high Beck Depression Inventory-II scores. Gut microbiota was characterized by 16S rRNA sequencing, and faecal metabolites were analysed via liquid chromatography-tandem mass spectrometry. Participants with depression exhibited significant differences in gut microbial composition and metabolic profiles. Differentially abundant taxa included Acidaminococcus, Christensenellaceae R-7 group, and Megasphaera, among others. Metabolomic analysis revealed 15 significantly altered metabolites, primarily lipids, organic acids, and benzenoids, some of which correlated with gut microbial features. This study highlights the interplay between the gut microbiota and depression, paving the way for future research to determine whether gut microbiota influences depression pathophysiology or reflects changes associated with depression. |
| Article's DOI: | 10.1038/s41522-025-00707-9 |
| Link to the original source: | https://www.nature.com/articles/s41522-025-00707-9 |
| Paper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Microbiology Biotechnology & applied microbiology Biotechnology Applied microbiology and biotechnology |
| Keywords: | Validity Tryptophan Tandem mass spectrometry Symptom severity Rna, ribosomal, 16s Population Multiomics Middle aged Metabolomics Metabolome Metabolism Mediterranean diet Male Lif Inflammation Humans Gene Gastrointestinal microbiome Female Feces Depression Cross-sectional studies Bacteria Aged |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2025-05-12 |
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| File | Description | Format | |
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| DocumentPrincipal | DocumentPrincipal | application/pdf |
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