Repositori institucional URV
| Autor/s de la URV: | Plaza Diaz, Julio Ramon |
| Autor segons l'article: | Lizama-Munoz, Asier; Plaza-Diaz, Julio |
| Adreça de correu electrònic de l'autor: | julioramon.plaza@urv.cat |
| Identificador de l'autor: | 0000-0002-5171-9408 |
| Any de publicació de la revista: | 2025 |
| Tipus de publicació: | Journal Publications |
| Referència de l'ítem segons les normes APA: | Lizama-Munoz, Asier; Plaza-Diaz, Julio (2025). Bispecific Antibodies, Nanobodies and Extracellular Vesicles: Present and Future to Cancer Target Therapy. Biomolecules, 15(5), 639-. DOI: 10.3390/biom15050639 |
| Referència a l'article segons font original: | Biomolecules. 15 (5): 639- |
| Resum: | Cancer remains one of the leading causes of mortality worldwide, with a growing need for precise and effective treatments. Traditional therapies such as chemotherapy and radiotherapy have limitations, including off-target effects and drug resistance. In recent years, targeted therapies have emerged as promising alternatives, aiming to improve treatment specificity and reduce systemic toxicity. Among the most innovative approaches, bispecific antibodies, nanobodies, and extracellular vesicles offer distinct and complementary mechanisms for cancer therapy. Bispecific antibodies enhance immune responses and enable dual-targeting of cancer cells, nanobodies provide superior tumor penetration due to their small size, and extracellular vesicles present a novel platform for drug and RNA delivery. This work aims to review and analyze these three approaches, assessing their current applications, advantages, challenges, and future perspectives. |
| DOI de l'article: | 10.3390/biom15050639 |
| Enllaç font original: | https://www.mdpi.com/2218-273X/15/5/639 |
| Versió de l'article dipositat: | info:eu-repo/semantics/publishedVersion |
| Accès a la llicència d'ús: | https://creativecommons.org/licenses/by/3.0/es/ |
| Departament: | Bioquímica i Biotecnologia |
| URL Document de llicència: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Àrees temàtiques: | Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry |
| Paraules clau: | Tria Target therapy Target therap Single-domain antibodies Neoplasms Nanobodies Molecular targeted therapy Humans Extracellular vesicles Engineering exosomes Egfr Drug delivery systems Cancer therapy Bispecific antibodies Biomarkers Antibodies, bispecific Animals |
| Entitat: | Universitat Rovira i Virgili |
| Data d'alta del registre: | 2025-06-07 |
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| Fitxer | Descripció | Format | |
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| DocumentPrincipal | DocumentPrincipal | application/pdf |
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