Articles producció científica> Ciències Mèdiques Bàsiques

Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of Metabolic Syndrome using SHROB rats as a model

  • Dades identificatives

    Identificador: PC:1459
    Handle: https://hdl.handle.net/20.500.11797/PC1459
    Autors:
    Montserrat GiraltGabriel DasilvaManuel PazosEduardo García-EgidoJara Pérez-JiménezJosep Lluis TorresMaría-Rosa NoguésIsabel Medina
    Resum:
    The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS.

  • Altres:

    Autor segons l'article: Montserrat Giralt; Gabriel Dasilva; Manuel Pazos; Eduardo García-Egido; Jara Pérez-Jiménez; Josep Lluis Torres; María-Rosa Nogués; Isabel Medina
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: GIRALT BATISTA, MONTSERRAT; Gabriel Dasilva; Manuel Pazos; Eduardo García-Egido; Jara Pérez-Jiménez; Josep Lluis Torres; NOGUÉS LLORT, MARIA ROSA; Isabel Medina
    Paraules clau: Metabolism FATTY ACIDS Biomarkers
    Resum: The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS.
    Grup de recerca: Farmacobiologia Cel.lular
    Àrees temàtiques: Health sciences Ciencias de la salud Ciències de la salut
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0308-8146
    Identificador de l'autor: S/D; S/D; S/D; S/D; S/D; S/D; S/D; S/D
    Data d'alta del registre: 2016-04-27
    Pàgina final: 203
    Volum de revista: 205
    Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0308814616303715?via%3Dihub
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1016/j.foodchem.2016.03.020
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2016
    Pàgina inicial: 196
    Tipus de publicació: Article Artículo Article

  • Paraules clau:

    METABOLISME
    ÀCIDS GRASSOS
    Metabolism
    FATTY ACIDS
    Biomarkers
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    0308-8146

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