Autor segons l'article: Sahebkar A, Hernández-Aguilera A, Abelló D, Sancho E, Camps J, Joven J.
Departament: Medicina i Cirurgia
Autor/s de la URV: CAMPS ANDREU, JORGE; HERNÁNDEZ AGUILERA, ANA; JOVEN MARIED, JORGE
Paraules clau: Cardiovascular risk HDL Hypertriglyceridemia
Resum: Objective A significant residual cardiovascular risk is consistently observed in patients treated with statins. A combined treatment with fibrates reduces cardiovascular events in very high-risk patients. Because this is apparently unconnected to an improvement in lipid-related outcomes we hypothesized that the cardioprotective effects of fibrates might be associated with an improvement in paraoxonase-1 (PON1) status. Method The search for existing evidence, using the Medline, Scopus and Cochrane databases, was systematic and followed the PRISMA statement without restrictions on publication date. We excluded non-clinical and observational studies and we extracted data on baseline and post-treatment values of serum PON1 activity and other measurements of PON1 status. Results Nine studies (including 12 treatment arms) in patients with hyperlipidemia, diabetes or metabolic syndrome treated with fibrates, alone or in combination with statins, were included to synthesize results. A meta-analysis of the data using a random-effects model revealed a significant increase in serum PON1 activity following fibrate therapy (WMD: 15.64 U/L, 95% CI: 6.94, 24.34, p < 0.001), an effect that was robust and not sensitive to any particular study. Subgroup analysis indicated differences in the effect size among types of fibrates and that PON1 alterations were associated with high-density lipoprotein cholesterol changes following fibrate therapy. Conclusions Results indicate a significant PON1-enhancing effect of fibrates. Whether this effect is associated with a clinical benefit, although likely, remains to be further investigated.
Grup de recerca: Unitat de Recerca Biomèdica
Àrees temàtiques: Ciències de la salut Ciencias de la salud Health sciences
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0026-0495
Identificador de l'autor: 0000-0003-0954-295X; 0000-0003-2749-4541
Data d'alta del registre: 2016-05-03
Pàgina final: 622
Volum de revista: 65
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.metabolismjournal.com/article/S0026-0495(16)00005-6/fulltext#%20
DOI de l'article: 10.1016/j.metabol.2016.01.002
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Pàgina inicial: 609
Tipus de publicació: Article Artículo Article
Repositori URV