Articles producció científica> Bioquímica i Biotecnologia

Effect of malabsorption on nutritional status and resting energy expenditure in HIV-infected patients

  • Dades identificatives

    Identificador: PC:1627
  • Autors:

    Jordi Salas Salvado
    Maria Jesus Jiménez Expósito
    Pilar Garcia Lorda
    Carlos Alfonso Villaverde
    Carmen M de Vírgala
    Rosa Solà
    Lluis Masana
    Victoria Arija
    Vicente Izquierdo
  • Altres:

    Autor segons l'article: Jordi Salas Salvado; Maria Jesus Jiménez Expósito; Pilar Garcia Lorda; Carlos Alfonso Villaverde; Carmen M de Vírgala; Rosa Solà; Lluis Masana; Victoria Arija; Vicente Izquierdo
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: SALAS SALVADÓ, JORGE; Maria Jesus Jiménez Expósito; Pilar Garcia Lorda; Carlos Alfonso Villaverde; Carmen M de Vírgala; Rosa Solà; Lluis Masana; Victoria Arija; Vicente Izquierdo
    Paraules clau: HIV infection aids malabsorption
    Resum: OBJECTIVE: To assess the influence of malabsorption on nutritional status and energy expenditure in patients at different stages of HIV infection. DESIGN AND METHODS: Fifty HIV patients were classified into three groups: Group 1, HIV asymptomatic patients (n=17); Group 2, AIDS without opportunistic infection (n=16); Group 3, AIDS patients with active infection (n=17). Clinically-healthy subjects (n=19) were used as controls. Parameters measured were: anthropometry, body composition by tetrapolar bioelectrical impedance; resting energy expenditure (REE) by open-circuit indirect calorimetry; malabsoption by D-xylose absorption and triolein breath tests. RESULTS: Malabsorption (defined as abnormality of xylose and/or fat absorption test) was found in 34 (68%) of patients: 9 (53%) Group 1; 11 (69%) Group 2; 14 (82%) Group 3. Twenty-seven (54%) had sugar malabsorption and 21 (42%) fat malabsorption. A significant relationship was observed between malabsorption and weight loss. REE measured was significantly lower in malabsorptive patients than in non-malabsorptive patients and controls (6006.3+/-846.5 versus 6443.4 + 985.5 versus 6802.1+/-862.7 kJ/day, respectively; P < 0.05). The REE adjusted for fat-free mass was lower in malabsorptive than in non-malabsorptive patients and slightly higher than in controls, although the differences were not statistically significant. CONCLUSIONS: The results suggest that malabsorption is a frequent feature in HIV infection and is related to the HIV-related weight loss. Hypermetabolism is not a constant phenomenon in HIV infection since, in the presence of malabsorption, our patients show an appropriate metabolic response with a compensatory decrease in REE.
    Grup de recerca: Alimentació, Nutrició, Creixement i Salut Mental
    Àrees temàtiques: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0269-9370
    Identificador de l'autor: orcid.org/0000-0003-2700-7459; N/D; orcid.org/0000-0001-8938-7229; N/D; N/D; orcid.org/0000-0002-8359-235X; orcid.org/0000-0002-0789-4954; orcid.org/0000-0002-1758-0975; N/D
    Data d'alta del registre: 2016-06-08
    Pàgina final: 1972
    Volum de revista: 12
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 1998
    Pàgina inicial: 1965
    Tipus de publicació: Article Artículo Article
  • Paraules clau:

    Sida
    VIH (Virus)
    Metabolisme energètic
    HIV infection
    aids
    malabsorption
    Bioquímica i biotecnologia
    Bioquímica y tecnología
    Biochemistry and technology
    0269-9370
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