Autor segons l'article: M Bullo Bonet; C Cabot; R Masanes; P Garcia-Lorda; JA Fernandez Lopez; J Salas Salvado; M Alemany
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: BULLÓ BONET, MÒNICA; C Cabot; R Masanes; P Garcia-Lorda; JA Fernandez Lopez; SALAS SALVADÓ, JORGE; M Alemany
Paraules clau: Plasma obese women
Resum: A group of obese women (BMI>27 kg/m2; N=73) was studied together with lean controls (BMI <27 kg/m2; N=25). Three groups were defined by the compliance with: BMI lower than 27 kg/m2, glycaemia lower than 5.5 mM and insulinaemia lower than 0.2 nM (controls, group 1, N=19). The subjects with BMI>27 kg/m2, glucose >5.5 mM and insulin >0.2 nM constituted group 3 (N=41), and those with BMI>27 with glycaemia and/or insulinaemia lower than the limits set constituted group 2 (N=32). The women in group 3 had higher fat content, BMI and fat-free mass than those in group 2 and the controls. There were no changes in most plasma parameters, such as free estrone and beta-estradiol. Leptin levels were higher in groups 2 and 3 than in controls. In controls, leptin and acyl-estrone levels were well correlated with BMI and fat content; this correlation was not found in groups 2 and 3 for acyl-estrone, although it was found for leptin. Acyl-estrone levels were lower than expected in most obese women when compared to those of controls, suggesting an altered availability or function of this hormone. In obese women, acyl-estrone levels -and probably function- are lower than expected, contrasting with maintained leptin-BMI correlations. The role of insulin in the control of body weight, perhaps through acyl estrone-mediated effects, should be re-evaluated.
Grup de recerca: Alimentació, Nutrició, Creixement i Salut Mental
Àrees temàtiques: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0743-5800
Identificador de l'autor: orcid.org/0000-0002-0218-7046; N/D; N/D; orcid.org/0000-0001-8938-7229; N/D; orcid.org/0000-0003-2700-7459; N/D
Data d'alta del registre: 2016-06-08
Pàgina final: 476
Volum de revista: 26
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2000
Pàgina inicial: 465
Tipus de publicació: Article Artículo Article
Repositori URV