Autor segons l'article: Jordi Salas ; Jean-Pierre Després; Alain Golay; Lars Sjöström; Rimonabant in Obesity
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: SALAS SALVADÓ, JORGE; Jean-Pierre Després; Alain Golay; Lars Sjöström; Rimonabant in Obesity
Paraules clau: dyslipidemia overweight Rimonabant
Resum: BACKGROUND:
Rimonabant, a selective cannabinoid-1 receptor (CB1) blocker, has been shown to reduce body weight and improve cardiovascular risk factors in obese patients. The Rimonabant in Obesity-Lipids (RIO-Lipids) study examined the effects of rimonabant on metabolic risk factors, including adiponectin levels, in high-risk patients who are overweight or obese and have dyslipidemia.
METHODS:
We randomly assigned 1036 overweight or obese patients (body-mass index [the weight in kilograms divided by the square of the height in meters], 27 to 40) with untreated dyslipidemia (triglyceride levels >1.69 to 7.90 mmol per liter, or a ratio of cholesterol to high-density lipoprotein [HDL] cholesterol of >4.5 among women and >5 among men) to double-blinded therapy with either placebo or rimonabant at a dose of 5 mg or 20 mg daily for 12 months in addition to a hypocaloric diet.
RESULTS:
The rates of completion of the study were 62.6 percent, 60.3 percent, and 63.9 percent in the placebo group, the group receiving 5 mg of rimonabant, and the group receiving 20 mg of rimonabant, respectively. The most frequent adverse events resulting in discontinuation of the drug were depression, anxiety, and nausea. As compared with placebo, rimonabant at a dose of 20 mg was associated with a significant (P<0.001) mean weight loss (repeated-measures method, -6.7+/-0.5 kg, and last-observation-carried-forward analyses, -5.4+/-0.4 kg), reduction in waist circumference (repeated-measures method, -5.8+/-0.5 cm, and last-observation-carried-forward analyses, -4.7+/-0.5 cm), increase in HDL cholesterol (repeated-measures method, +10.0+/-1.6 percent, and last-observation-carried-forward analyses, +8.1+/-1.5 percent), and reduction in triglycerides (repeated-measures method, -13.0+/-3.5 percent, and last-observation-carried-forward analyses, -12.4+/-3.2 percent). Rimonabant at a dose of 20 mg also resulted in an increase in plasma adiponectin levels (repeated-measures method, 57.7 percent, and last-observation-carried-forward analyses, 46.2 percent; P<0.001), for a change that was partly independent of weight loss alone.
CONCLUSIONS:
Selective CB1-receptor blockade with rimonabant significantly reduces body weight and waist circumference and improves the profile of several metabolic risk factors in high-risk patients who are overweight or obese and have an atherogenic dyslipidemia.
Grup de recerca: Alimentació, Nutrició, Creixement i Salut Mental
Àrees temàtiques: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0028-4793
Identificador de l'autor: N/D; N/D; N/D; N/D; N/D
Data d'alta del registre: 2016-06-10
Pàgina final: 2134
Volum de revista: 353
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.nejm.org/doi/full/10.1056/NEJMoa044537
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1056/NEJMoa044537
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2005
Pàgina inicial: 2121
Tipus de publicació: Article Artículo Article
Repositori URV