Autor segons l'article: Oscar Pàmies; Jèssica Margalef; Montserrat Diéguez
Departament: Química Física i Inorgànica
Autor/s de la URV: PAMIES OLLÉ, OSCAR; Jèssica Margalef; DIÉGUEZ FERNÁNDEZ, MONTSERRAT
Paraules clau: asymmetric transfer hydrogenation ketones sugar-based ligands
Resum: Asymmetric transfer hydrogenation (ATH) has emerged as one of the most effective and sustainable synthetic
tool for synthesizing enantiopure alcohols. Since Noyori’s group successfully applied Ru-catalysts
modified with chiral b-amino alcohols or diamines as ligands, a large number of catalytic systems has
been successfully developed. However, further improvement in terms of substrate scope, selectivity,
and turnover frequency are required to make the process competitive with conventional hydrogenations.
Overcoming these limitations requires research toward the design of new ligands. Such a task becomes
easier if readily modulable chiral ligands are at hand. Sugar-based ligands are particularly useful for
addressing this need. They are readily available, highly functionalized, and their modular constructions
are easy. Series of chiral ligands can be screened in the search for high activities and selectivities for each
type of substrate. This digest paper will discuss the progress on the use of sugar-based ligands in ATH
reactions.
Grup de recerca: Organometàl.lics i Catàlisi Homogènia
Àrees temàtiques: Química Química Chemistry
Accès a la llicència d'ús: thttps://creativecommons.org/licenses/by/3.0/es/
ISSN: 0040-4039
Identificador de l'autor: 0000-0002-2352-8508; n/a; 0000-0002-8450-0656
Data d'alta del registre: 2017-02-22
Pàgina final: 1308
Volum de revista: 57
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0040403916301320
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: https://doi.org/10.1016/j.tetlet.2016.02.022
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Pàgina inicial: 1301
Tipus de publicació: Post-print
Repositori URV