Articles producció científica> Medicina i Cirurgia

Nutrients in energy and one-carbon metabolism: Learning from metformin users

  • Dades identificatives

    Identificador: PC:2585
    Autors:
    Camps, J.Luciano-Mateo, F.Hernández-Aguilera, A.Cabre, N.Fernández-Arroyo, S.Lopez-Miranda, J.Menendez, J.A.Joven, J.
    Resum:
    Review DOI: 10.3390/nu9020121 URL: http://www.mdpi.com/2072-6643/9/2/121 Filiació URV: SI Memòria
  • Altres:

    Autor segons l'article: Camps, J.; Luciano-Mateo, F.; Hernández-Aguilera, A.; Cabre, N.; Fernández-Arroyo, S.; Lopez-Miranda, J.; Menendez, J.A.; Joven, J.
    Departament: Medicina i Cirurgia
    Autor/s de la URV: CAMPS ANDREU, JORGE; Luciano-Mateo, F.; Hernández-Aguilera, A.; Cabre, N.; Fernández-Arroyo, S.; Lopez-Miranda, J.; Menendez, J.A.; JOVEN MARIED, JORGE
    Paraules clau: obesity Energy intake Diabetes mellitus
    Resum: Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations.
    Grup de recerca: Unitat de Recerca Biomèdica
    Àrees temàtiques: Health sciences Ciencias de la salud Ciències de la salut
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2072-6643
    Identificador de l'autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Data d'alta del registre: 2017-03-06
    Volum de revista: 9
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2072-6643/9/2/121
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.3390/nu9020121
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Pàgina inicial: Art.num. 121
    Tipus de publicació: Article Artículo Article
  • Paraules clau:

    Metabolisme energètic
    Obesitat
    Diabetis
    obesity
    Energy intake
    Diabetes mellitus
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    2072-6643
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