Autor segons l'article: Romeu, M.; Dasilva, G.; Pazos, M.; García-Egido, E.; Gallardo, J.M.; Ramos-Romero, S.; Torres, J.L.; Nogués, M.-R.; Medina, I.
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: ROMEU FERRAN, MARTA.; NOGUÉS LLORT, MARIA ROSA
Paraules clau: inflammation Fish oils eicosanoids
Resum: The ability of polyphenols to ameliorate potential oxidative damage of ω-3 PUFAs when they are consumed together and then, to enhance their potentially individual effects on metabolic health is discussed through the modulation of fatty acids profiling and the production of lipid mediators. For that, the effects of the combined consumption of fish oils and grape seed procyanidins on the inflammatory response and redox unbalance triggered by high-fat high-sucrose (HFHS) diets were studied in an animal model of Wistar rats. A standard diet was used as control. Results suggested that fish oils produced a replacement of ω-6 by ω-3 PUFAs in membranes and tissues, and consequently they improved inflammatory and oxidative stress parameters: favored the activity of 12/15-lipoxygenases on ω-3 PUFAs, enhanced glutathione peroxidases activity, modulated proinflammatory lipid mediators synthesis through the cyclooxygenase (COX) pathways and down-regulated the synthesis de novo of ARA leaded by Δ5 desaturase. Although polyphenols exerted an antioxidative and antiinflammatory effect in the standard diet, they were less effective to reduce inflammation in the HFHS dietary model. Contrary to the effect observed in the standard diet, polyphenols up-regulated COX pathways toward ω-6 proinflammatory eicosanoids as PGE2 and 11-HETE and decreased the detoxification of ω-3 hydroperoxides in the HFHS diet. As a result, additive effects between fish oils and polyphenols were found in the standard diet in terms of reducing inflammation and oxidative stress. However, in the HFHS diets, fish oils seem to be the one responsible for the positive effects found in the combined group.
Grup de recerca: Farmacobiologia Cel.lular
Àrees temàtiques: Health sciences Ciencias de la salud Ciències de la salut
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0955-2863
Data d'alta del registre: 2017-03-14
Pàgina final: 67
Volum de revista: 43
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: http://www.sciencedirect.com/science/article/pii/S0955286316303059Memòria
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1016/j.jnutbio.2017.02.007
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Pàgina inicial: 53
Tipus de publicació: Article Artículo Article
Repositori URV