Autor segons l'article: Nadal, L.; Garcia, N.; Hurtado, E.; Simó, A.; Tomàs, M.; Lanuza, M.A.; Cilleros, V.; Tomàs, J.
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: NADAL MAGRIÑÀ, LAURA; Garcia, N.; HURTADO CABALLERO, ERICA; SIMÓ OLLÉ, ANNA; TOMAS MARGINET, MARTA; LANUZA ESCOLANO, MARÍA ANGEL; CILLEROS MAÑÉ, VÍCTOR; Tomàs, J.
Paraules clau: cholinergic synapses motor nerve terminal Neuromuscular junction
Resum: The development of the nervous system involves the overproduction of synapses but connectivity is refined by Hebbian activity-dependent axonal competition. The newborn skeletal muscle fibers are polyinnervated but, at the end of the competition process, some days later, become innervated by a single axon. We used quantitative confocal imaging of the autofluorescent axons from transgenic B6.Cg-Tg (Thy1-YFP)16 Jrs/J mice to investigate the possible cooperation of the muscarinic autoreceptors (mAChR, M1-, M2- and M4-subtypes) and the tyrosine kinase B (TrkB) receptor in the control of axonal elimination after the mice Levator auris longus (LAL) muscle had been exposed to several selective antagonist of the corresponding receptor pathways in vivo. Our previous results show that M1, M2 and TrkB signaling individually increase axonal loss rate around P9. Here we show that although the M1 and TrkB receptors cooperate and add their respective individual effects to increase axonal elimination rate even more, the effect of the M2 receptor is largely independent of both M1 and TrkB receptors. Thus both, cooperative and non-cooperative signaling mechanisms contribute to developmental synapse elimination.
Grup de recerca: Unitat d'Histologia i Neurobiologia
Àrees temàtiques: Ciències de la salut Ciencias de la salud Health sciences
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1663-4365
Identificador de l'autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
Data d'alta del registre: 2017-03-21
Volum de revista: 9
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.frontiersin.org/articles/10.3389/fnagi.2017.00024/full
DOI de l'article: 10.3389/fnagi.2017.00024
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Pàgina inicial: Art.num. 24
Tipus de publicació: Article Artículo Article
Repositori URV