Autor segons l'article: Hernández-Alonso P, Cañueto D, Giardina S, Salas-Salvadó J, Cañellas N, Correig X, Bulló M.
Departament: Enginyeria Electrònica Bioquímica i Biotecnologia
Autor/s de la URV: Hernández-Alonso, P.; Cañueto, D.; Giardina, S.; SALAS SALVADÓ, JORGE; CAÑELLAS ALBERICH, NICOLAU; CORREIG BLANCHAR, FRANCESC XAVIER; BULLÓ BONET, MÒNICA
Paraules clau: Microbiota metabolomics Insulin resistance
Resum: The specific nutritional composition of nuts could affect different metabolic pathways involved in a broad range of metabolic diseases. We therefore investigated whether chronic consumption of pistachio nuts modifies the urine metabolome in prediabetic subjects. We designed a randomized crossover clinical trial in 39 prediabetic subjects. They consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57 g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Nuclear magnetic resonance (NRM) was performed to determine changes in 24-h urine metabolites. Significant changes in urine metabolites according to the different intervention periods were found in uni- and multivariate analysis. Score plot of the first two components of the multilevel partial least squares discriminant analysis (ML-PLS-DA) showed a clear separation of the intervention periods. Three metabolites related with gut microbiota metabolism (i.e., hippurate, p-cresol sulfate and dimethylamine) were found decreased in PD compared with CD (P<.05). Moreover, cis-aconitate [intermediate of the tricarboxylic acid (TCA)] was also found decreased following PD compared with CD. Intragroup analysis showed that creatinine levels were significantly increased in PD (P=.023), whereas trimethylamine N-oxide (TMAO) was found significantly reduced following PD (P=.034). Our results suggest that chronic pistachio consumption may modulate some urinary metabolites related to gut microbiota metabolism and the TCA cycle; all associated with metabolic derangements associated with insulin resistance and Type 2 diabetes.
Grup de recerca: Signal Processing for Omic Sciences Alimentació, Nutrició, Creixement i Salut Mental
Àrees temàtiques: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0955-2863
Identificador de l'autor: orcid.org/0000-0003-2700-7459; N/D; N/D; N/D; orcid.org/0000-0003-4856-8132; orcid.org/0000-0002-6902-3054; orcid.org/0000-0002-0218-7046
Data d'alta del registre: 2017-05-03
Pàgina final: 53
Volum de revista: 45
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0955286316306490?via%3Dihub
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1016/j.jnutbio.2017.04.002
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Pàgina inicial: 48
Tipus de publicació: Article Artículo Article