Autor segons l'article: Pinent, M. Ardèvol, A. Blay, M. Martínez, N. González, N.
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: http://pubs.acs.org/doi/pdf/10.1021/jf405239p
Departament: Bioquímica i Biotecnologia
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Autor/s de la URV: Noemi González-Abuín; Neus Martínez-Micaelo; Mayte Blay; Anna Ardévol; Montserrat Pinent
Resum: Grape-seed procyanidin extract (GSPE) has been reported to improve insulin resistance in cafeteria rats. Because glucagon-like peptide-1 (GLP-1) is involved in glucose homeostasis, the preventive effects of GSPE on GLP-1 production, secretion, and elimination were evaluated in a model of diet-induced insulin resistance. Rats were fed a cafeteria diet for 12 weeks, and 25 mg of GSPE/kg of body weight was administered concomitantly. Vehicle-treated cafeteria-fed rats and chow-fed rats were used as controls. The cafeteria diet decreased active GLP-1 plasma levels, which is attributed to a decreased intestinal GLP-1 production, linked to reduced colonic enteroendocrine cell populations. Such effects were prevented by GSPE. In the same context, GSPE avoided the decrease on intestinal dipeptidyl-peptidase 4 (DPP4) activity and modulated the gene expression of GLP-1 and its receptor in the hypothalamus. In conclusion, the preventive treatment with GSPE abrogates the effects of the cafeteria diet on intestinal GLP-1 production and DPP4 activity.
Entitat: Universitat Rovira i Virgili.
Any de publicació de la revista: 2014
Pàgina inicial: 1066
Pàgina final: 1072
Volum de revista: 62
Repositori URV