Articles producció científica> Medicina i Cirurgia

Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth

  • Dades identificatives

    Identificador: imarina:2620848
    Autors:
    Martinez-Perez, BrunoEjarque, MiriamGutierrez, CristinaNunez-Roa, CatalinaRoche, KellyVila-Bedmar, RocioBallesteros, MonicaRedondo-Angulo, IbonPlanavila, AnnaVillarroya, FrancescVendrell, JoanFernandez-Veledo, SoniaMegia, Ana
    Resum:
    Angiopoietin-like protein 8 (ANGPTL8), a protein implicated in lipid and glucose homeostasis, is present only in mammals, suggesting that it is involved in processes unique to these vertebrates such as pregnancy and homeothermy. We explored the role of ANGPTL8 in maternal-fetal crosstalk and its relationship with newborn adiposity. In a longitudinal analysis of healthy pregnant women, ANGPTL8 levels decreased progressively during pregnancy although remained higher than levels in the postpartum period. In a cross-sectional observational study of women with or without gestational diabetes mellitus (GDM), and their offspring, ANGPTL8 levels were higher in venous cord blood than those in maternal blood and were significantly lower in GDM patients than those in healthy women. Infants small for gestational age and with low-fat mass had the highest ANGPTL8 cord blood levels. Studies in vitro revealed that ANGPTL8 was secreted by brown adipocytes and its expression was increased in experimental models of white-to-brown fat conversion. In addition, ANGPTL8 induced the expression of markers of brown adipocytes. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.Copyright © 2016 Elsevier Inc. All rights reserved.
  • Altres:

    Autor segons l'article: Martinez-Perez, Bruno; Ejarque, Miriam; Gutierrez, Cristina; Nunez-Roa, Catalina; Roche, Kelly; Vila-Bedmar, Rocio; Ballesteros, Monica; Redondo-Angulo, Ibon; Planavila, Anna; Villarroya, Francesc; Vendrell, Joan; Fernandez-Veledo, Sonia; Megia, Ana;
    Departament: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/s de la URV: Fernandez Veledo, Sonia / Megía Colet, Ana / Vendrell Ortega, Juan José
    Paraules clau: Obesity Lipid-metabolism Insulin-resistance Gestational diabetes-mellitus Fat Fasting plasma-glucose Cord blood irisin Circulating betatrophin levels Birth-weight Beta-cell proliferation
    Resum: Angiopoietin-like protein 8 (ANGPTL8), a protein implicated in lipid and glucose homeostasis, is present only in mammals, suggesting that it is involved in processes unique to these vertebrates such as pregnancy and homeothermy. We explored the role of ANGPTL8 in maternal-fetal crosstalk and its relationship with newborn adiposity. In a longitudinal analysis of healthy pregnant women, ANGPTL8 levels decreased progressively during pregnancy although remained higher than levels in the postpartum period. In a cross-sectional observational study of women with or without gestational diabetes mellitus (GDM), and their offspring, ANGPTL8 levels were higher in venous cord blood than those in maternal blood and were significantly lower in GDM patients than those in healthy women. Infants small for gestational age and with low-fat mass had the highest ANGPTL8 cord blood levels. Studies in vitro revealed that ANGPTL8 was secreted by brown adipocytes and its expression was increased in experimental models of white-to-brown fat conversion. In addition, ANGPTL8 induced the expression of markers of brown adipocytes. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.Copyright © 2016 Elsevier Inc. All rights reserved.
    Grup de recerca: Grup de Recerca Biomèdica HJ23
    Àrees temàtiques: Saúde coletiva Public health, environmental and occupational health Physiology (medical) Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Medical laboratory technology Interdisciplinar General medicine Farmacia Ciências biológicas ii Ciências biológicas i Ciências ambientais Biochemistry (medical)
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 19315244
    Adreça de correu electrònic de l'autor: sonia.fernandez@urv.cat ana.megia@urv.cat juanjose.vendrell@urv.cat
    Identificador de l'autor: 0000-0003-2906-3788 0000-0002-5101-9452 0000-0002-6994-6115
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.translationalres.com/article/S1931-5244(16)30105-0/fulltext
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Translational Research. 178 1-12
    Referència de l'ítem segons les normes APA: Martinez-Perez, Bruno; Ejarque, Miriam; Gutierrez, Cristina; Nunez-Roa, Catalina; Roche, Kelly; Vila-Bedmar, Rocio; Ballesteros, Monica; Redondo-Angul (2016). Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth. Translational Research, 178(), 1-12. DOI: 10.1016/j.trsl.2016.06.012
    DOI de l'article: 10.1016/j.trsl.2016.06.012
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2016
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry (Medical),Medical Laboratory Technology,Medicine (Miscellaneous),Medicine, General & Internal,Medicine, Research & Experimental,Physiology (Medical),Public Health, Environmental and Occupational Health
    Obesity
    Lipid-metabolism
    Insulin-resistance
    Gestational diabetes-mellitus
    Fat
    Fasting plasma-glucose
    Cord blood irisin
    Circulating betatrophin levels
    Birth-weight
    Beta-cell proliferation
    Saúde coletiva
    Public health, environmental and occupational health
    Physiology (medical)
    Medicine, research & experimental
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Medical laboratory technology
    Interdisciplinar
    General medicine
    Farmacia
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Biochemistry (medical)
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