Autor segons l'article: Serena C., Keiran N., Madeira A., Maymó-Masip E., Ejarque M., Terrón-Puig M., Espin E., Martí M., Borruel N., Guarner F., Menacho M., Zorzano A., Millan M., Fernández-Veledo S., Vendrell J.
Departament: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
Autor/s de la URV: Fernandez Veledo, Sonia / Keiran Fernandez, Noelia Elisabeth / Maymo Masip, Elsa / Serena Perelló, Carolina / Terrón Puig, Margarida Maria / Vendrell Ortega, Juan José
Paraules clau: Regulatory t cell Regulatory t cell Phagocytosis Migration Mesenchymal stem cells Lymphocytes Invasion Interleukin 1b Immunity Creeping fat Cell therapy phagocytosis migration mesenchymal stem cells lymphocytes invasion interleukin 1b immunity creeping fat cell therapy
Resum: Crohn's disease (CD) is characterized by the expansion of mesenteric fat, also known as "creeping fat." We explored the plasticity and immune properties of adipose-derived stem cells (ASCs) in the context of CD as potential key players in the development of creeping fat. Mesenteric CD-derived ASCs presented a more proliferative, inflammatory, invasive, and phagocytic phenotype than equivalent cells from healthy donors, irrespective of the clinical stage. Remarkably, ASCs from the subcutaneous depot of patients with CD also showed an activated immune response that was associated with a reduction in their immunosuppressive properties. The invasive phenotype of mesenteric CD ASCs was governed by an inflammasome-mediated inflammatory state since blocking inflammasome signaling, mainly the secretion of interleukin-1?, reversed this characteristic. Thus, CD alters the biological functions of ASCs as adipocyte precursors, but also their immune properties. Selection of ASCs with the best immunomodulatory properties is advocated for the success of cell-based therapies.Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
Àrees temàtiques: Medicina i Genetics Developmental biology Cell biology Cell & tissue engineering Biochemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 22136711
Adreça de correu electrònic de l'autor: carolina.serena@urv.cat elsa.maymo@urv.cat margaridamaria.terron@estudiants.urv.cat sonia.fernandez@urv.cat juanjose.vendrell@urv.cat
Identificador de l'autor: 0000-0002-9133-3120 0000-0003-2906-3788 0000-0002-6994-6115
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30324-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213671117303247%3Fshowall%3Dtrue
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Stem Cell Reports. 9 (4): 1109-1123
Referència de l'ítem segons les normes APA: Serena C., Keiran N., Madeira A., Maymó-Masip E., Ejarque M., Terrón-Puig M., Espin E., Martí M., Borruel N., Guarner F., Menacho M., Zorzano A., Mill (2017). Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation. Stem Cell Reports, 9(4), 1109-1123. DOI: 10.1016/j.stemcr.2017.07.014
DOI de l'article: 10.1016/j.stemcr.2017.07.014
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Tipus de publicació: Journal Publications
Repositori URV