Autor segons l'article: Valls RM, Llauradó E, Fernández-Castillejo S, Puiggrós F, Solà R, Arola L, Pedret A
Departament: Bioquímica i Biotecnologia Medicina i Cirurgia
Autor/s de la URV: Arola Ferrer, Luis Maria / FERNÁNDEZ CASTILLEJO, SARA / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / Solà Alberich, Rosa Maria
Paraules clau: Systolic blood pressure Low weight molecular procyanidin Hdl-c Cardiovascular biomarkers low weight molecular procyanidin hdl-c cardiovascular biomarkers
Resum: Background Oligopin¿ (OP) is a quantified extract from French Maritime Pine bark (FMPB) with low molecular weight procyanidins. The cardioprotective effects of OP need to be tested in human clinical intervention trials with an appropriate design. Purpose The aim of the present study was to assess the effect of subchronic consumption of OP on cardiovascular disease risk factors such as lipid profile, systolic blood pressure (BP) and oxidized-Low Density Lipoprotein (ox-LDL) in stage-1-hypertensive subjects. Methods Between February 14 and May 31, 2014, eligible subjects were recruited from the outpatient clinics of Hospital Universitari Sant Joan (Reus, Spain). A total of 24 participants (mean age ± DS; 57.36 ± 11.25; 17 men) with stage-1-hypertension who were not receiving BP-lowering medication and LDL cholesterol < 4.88 mmol/l were randomized in a double-blind, placebo-controlled, crossover study. The subjects received 2 capsules/day with 75 mg of OP or placebo for 5-weeks. Results At 5-weeks, compared to the placebo, OP raised High Density Lipoprotein-cholesterol (HDL-c) by 14.06% (p = 0.012) and apolipoprotein A-1 by 8.12% (p = 0.038) and reduced the ratio of apolipoprotein B-100/A-1 by 10.26% (p = 0.046). Moreover, at 5-weeks, compared to the baseline, OP reduced the systolic BP by 6.36 mmHg (p = 0.014), and decreased ox-LDL concentrations by 31.72 U/l (p = 0.015). Conclusion At 5-weeks, the consumption of 150 mg/day of OP improve lipid cardiovascular profile and represents one of the scarce ways to increase HDL-c in stage-1-hypertensive subjects.
Àrees temàtiques: Saúde coletiva Química Plant sciences Planejamento urbano e regional / demografia Pharmacology & pharmacy Pharmacology Pharmaceutical science Odontología Nutrição Molecular medicine Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Integrative & complementary medicine General medicine Farmacia Engenharias ii Enfermagem Drug discovery Complementary and alternative medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09447113
Adreça de correu electrònic de l'autor: anna.pedret@urv.cat elisabet.llaurado@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
Identificador de l'autor: 0000-0002-5327-932X 0000-0002-7439-9531 0000-0002-8359-235X 0000-0003-2767-1974
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0944711316301490
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Phytomedicine. 23 (12): 1451-1461
Referència de l'ítem segons les normes APA: Valls RM, Llauradó E, Fernández-Castillejo S, Puiggrós F, Solà R, Arola L, Pedret A (2016). Effects of low molecular weight procyanidin rich extract from french maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial. Phytomedicine, 23(12), 1451-1461. DOI: 10.1016/j.phymed.2016.08.007
DOI de l'article: 10.1016/j.phymed.2016.08.007
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Tipus de publicació: Journal Publications
Repositori URV