Autor segons l'article: García-Calzón S, Martínez-González MA, Razquin C, Corella D, Salas-Salvadó J, Martínez JA, Zalba G, Marti A.
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Salas Salvadó, Jorge
Paraules clau: Telomere Nutrigenomics Genetic polymorphism Diet nutrigenomics genetic polymorphism diet
Resum: Background - The gene variant Pro/Ala (rs1801282) in the PPARγ2 has been associated with lower cardiovascular risk and greater benefit from lifestyle interventions. This polymorphism also seems to be associated with longer lifespan, but no information on telomere length (TL) is available. Our aim was to study the association between the Ala allele and changes in TL in high cardiovascular risk subjects and the potential interaction with a Mediterranean dietary pattern. Methods and Results - A total of 521 subjects (55-80 years) participating in the Prevención con Dieta Mediterránea randomized trial were genotyped. Changes in TL, measured by quantitative real-time polymerase chain reaction (PCR), were assessed over 5 years of a nutritional intervention, which promoted adherence to the Mediterranean diet (MeDiet). Interestingly, Ala carriers showed lower telomere shortening after 5 years compared with the Pro/Pro genotype (P=0.031). This association was modulated by MeDiet because those Ala carriers who reported better conformity to the MeDiet exhibited increased TL (P<0.001). Moreover, a reduction in carbohydrate intake (≤9.5 g/d) resulted in increased TL among Ala carriers. Notably, an apparent gene-diet interaction was found through the observed changes in the MUFA+PUFA/carbohydrates ratio: as this ratio increased, TL lengthening was detected to a greater extent in the Ala carriers compared with the Pro/Pro subjects (P for interaction <0.001). Conclusions - The Pro12Ala polymorphism is associated with TL homeostasis after 5 years follow-up in subjects at high cardiovascular risk. In addition, a higher adherence to the MeDiet pattern strengthens the prevention of telomere shortening among Ala carriers. Clinical Trial Registration - www.controlled-trials.com; Unique Identifier: ISRCTN35739639. © 2014 American Heart Association, Inc.
Àrees temàtiques: Medicine (miscellaneous) Genetics (clinical) Genetics & heredity Genetics General medicine Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: jordi.salas@urv.cat
Identificador de l'autor: 0000-0003-2700-7459
Data d'alta del registre: 2024-08-03
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.114.000635
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Circulation-Cardiovascular Genetics. 8 (1): 91-99
Referència de l'ítem segons les normes APA: García-Calzón S, Martínez-González MA, Razquin C, Corella D, Salas-Salvadó J, Martínez JA, Zalba G, Marti A. (2015). Pro12Ala polymorphism of the PPARγ2 gene interacts with a Mediterranean diet to prevent telomere shortening in the PREDIMED-NAVARRA randomized trial. Circulation-Cardiovascular Genetics, 8(1), 91-99. DOI: 10.1161/CIRCGENETICS.114.000635
DOI de l'article: 10.1161/CIRCGENETICS.114.000635
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2015
Tipus de publicació: Journal Publications
Repositori URV