Autor segons l'article: López de las Hazas M., Piñol C., Macià A., Romero M., Pedret A., Solà R., Rubió L., Motilva M.
Departament: Medicina i Cirurgia
Autor/s de la URV: Pedret Figuerola, Anna / Solà Alberich, Rosa Maria
Paraules clau: Phenolic compounds Olive oil Microbial catabolism Metabolic pathways Hydroxytyrosol
Resum: This study investigated and compared the absorption, metabolism, and subsequently, the tissue distribution and excretion of hydroxytyrosol (HT) administered either in its free form or through its naturally occurring esterified precursors, namely oleuropein (OLE) and its aglycone forms known as secoiridoids (SEC). Here, rats were fed a diet supplemented with the equivalent of 5 mg phenol/kg/day for 21 days and the HT metabolites in the gastrointestinal digesta (stomach, small intestine and caecum), plasma, urine and metabolic tissues (liver and kidney) were analysed. Compared to HT and SEC, OLE showed greater stability during digestion, and, consequently, the bioavailability based on the urine excretion of HT metabolites was higher. OLE, as a glycoside molecule, reached the colon unaltered generating more diverse microbial metabolites. In terms of bioavailability, findings suggest that OLE might be the most suitable precursor of HT for incorporation into foods or nutraceutical formulations.
Grup de recerca: Unitat de Recerca de Lípids i Arteriosclerosi
Àrees temàtiques: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 17564646
Adreça de correu electrònic de l'autor: anna.pedret@urv.cat rosa.sola@urv.cat
Identificador de l'autor: 0000-0002-5327-932X 0000-0002-8359-235X
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S1756464616000335
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Journal Of Functional Foods. 22 52-63
Referència de l'ítem segons les normes APA: López de las Hazas M., Piñol C., Macià A., Romero M., Pedret A., Solà R., Rubió L., Motilva M. (2016). Differential absorption and metabolism of hydroxytyrosol and its precursors oleuropein and secoiridoids. Journal Of Functional Foods, 22(), 52-63. DOI: 10.1016/j.jff.2016.01.030
DOI de l'article: 10.1016/j.jff.2016.01.030
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Tipus de publicació: Journal Publications
Repositori URV