Autor segons l'article: Gattere G, Stojanovic-Pérez A, Monseny R, Martorell L, Ortega L, Montalvo I, Solé M, Algora MJ, Cabezas Á, Reynolds RM, Vilella E, Labad J.
Departament: Medicina i Cirurgia Infermeria
Autor/s de la URV: Martorell Bonet, Lourdes / Ortega Sanz, Laura / Vilella Cuadrada, Elisabet
Paraules clau: Stress Early psychosis Diet Brain-derived neurotrophic factor Bdnf val66met early psychosis diet brain-derived neurotrophic factor
bdnf val66met
bdnf val66met
Resum: The brain-derived neurotrophic factor (BDNF) is a major participant in the regulation of food intake and may play a role in the regulation of the stress response. We aimed to investigate whether there is a gene-environment interaction in the relationship between stress and BDNF Val66Met polymorphism in relation to dietary patterns in a sample of subjects with early psychosis.We studied 124 early psychotic disorder (PD) patients, 36 At-Risk Mental States (ARMS) and 62 healthy subjects (HS). Dietary patterns were examined by a dietician. Physical activity, life stress and perceived stress were assessed by validated questionnaires. BDNF Val66Met polymorphism (rs6265) was genotyped. A gene-environment interaction was tested with multiple linear regression analysis while adjusting for covariates.Perceived stress was not associated with calorie intake in HS. In ARMS subjects, Met-carriers who presented low-perceived stress were associated with increased caloric intake. Conversely, those who presented high-perceived stress were associated with reduced caloric intake. In PD, perceived stress was neither associated with increased calorie intake without an effect by BDNF genotype nor a gene-environment interaction. Perceived stress was associated with food craving in PD patients, independent of genotype, and in ARMS or HS who were Val homozygous.This study suggests that the common Val66Met polymorphism of the BDNF gene may modulate the relationship between life stress and calorie intake in subjects at risk for psychosis.© 2016 John Wiley & Sons Australia, Ltd.
Àrees temàtiques: Psychiatry and mental health Psychiatry Psychiatric mental health Medicina ii Medicina i General medicine Ciencias sociales Biological psychiatry
ISSN: 17517885
Adreça de correu electrònic de l'autor: lourdes.martorell@urv.cat elisabet.vilella@urv.cat laura.ortega@urv.cat
Identificador de l'autor: 0000-0003-4999-2197 0000-0002-1887-5919 0000-0003-2476-7700
Data d'alta del registre: 2023-02-22
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/abs/10.1111/eip.12371
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Early Intervention In Psychiatry. 12 (5): 811-820
Referència de l'ítem segons les normes APA: Gattere G, Stojanovic-Pérez A, Monseny R, Martorell L, Ortega L, Montalvo I, Solé M, Algora MJ, Cabezas Á, Reynolds RM, Vilella E, Labad J. (2018). Gene-environment interaction between the brain-derived neurotrophic factor Val66Met polymorphism, psychosocial stress and dietary intake in early psychosis.. Early Intervention In Psychiatry, 12(5), 811-820. DOI: 10.1111/eip.12371
DOI de l'article: 10.1111/eip.12371
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Tipus de publicació: Journal Publications
Repositori URV