Articles producció científica> Medicina i Cirurgia

Ten years of follow-up of the Spanish cohort of the European PreventCD study: the lessons learned

  • Dades identificatives

    Identificador: imarina:4104944
    Autors:
    Crespo Escobar PCastillejo GMartínez-Ojinaga EDonat EPolanco IMearin MRibes-Koninckx C
    Resum:
    AIM: to evaluate the influence of gluten consumption on celiac disease development and to describe its natural history in the Spanish cohort of the European PreventCD study. METHODS: prospective multi-center double blind study of 225 children that were followed up from birth. All cases were HLA-DQ2/HLA-DQ8 positive with a 1st degree relative with celiac disease and were followed up in three centers from Madrid, Reus and Valencia. Gluten intake was determined between four and ten months according to the protocol. Gluten intake was ad libitum between eleven and 36 months and was prospectively quantified by means of dietary records. Clinical visits and specific antibody analysis for celiac disease were performed periodically. RESULTS: twenty-six cases were diagnosed, all had a positive biopsy and serology; 21 had gastrointestinal symptoms and five were asymptomatic. In addition, 2,565 food records were analyzed and statistically significant differences (p < 0.001) were found with regard to gluten consumption among the three centers, although not between celiac and non-celiac children (p = 0.025). The HLA-DQ2.5/DQ2.5 and DQ2.5/DQ2.2 genotypes had a relative risk of 4.7 (95% CI: 0.80-27.55; p = 0.08), which was higher than for the rest of genotypes. Female gender also had a relative risk that was five times higher than that for males. CONCLUSIONS: the amount of gluten intake between 11 and 36 months or the duration of breast feeding were not risk factors for the development of CD in the Spanish population. The HLA genotype and gender were the most relevant associated factors. In this at-risk group, the disease presented before two years of age in the majority of the cases with a weak clinical expression.
  • Altres:

    Autor segons l'article: Crespo Escobar P; Castillejo G; Martínez-Ojinaga E; Donat E; Polanco I; Mearin M; Ribes-Koninckx C
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Castillejo De Villasante, Gemma
    Paraules clau: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag
    Resum: AIM: to evaluate the influence of gluten consumption on celiac disease development and to describe its natural history in the Spanish cohort of the European PreventCD study. METHODS: prospective multi-center double blind study of 225 children that were followed up from birth. All cases were HLA-DQ2/HLA-DQ8 positive with a 1st degree relative with celiac disease and were followed up in three centers from Madrid, Reus and Valencia. Gluten intake was determined between four and ten months according to the protocol. Gluten intake was ad libitum between eleven and 36 months and was prospectively quantified by means of dietary records. Clinical visits and specific antibody analysis for celiac disease were performed periodically. RESULTS: twenty-six cases were diagnosed, all had a positive biopsy and serology; 21 had gastrointestinal symptoms and five were asymptomatic. In addition, 2,565 food records were analyzed and statistically significant differences (p < 0.001) were found with regard to gluten consumption among the three centers, although not between celiac and non-celiac children (p = 0.025). The HLA-DQ2.5/DQ2.5 and DQ2.5/DQ2.2 genotypes had a relative risk of 4.7 (95% CI: 0.80-27.55; p = 0.08), which was higher than for the rest of genotypes. Female gender also had a relative risk that was five times higher than that for males. CONCLUSIONS: the amount of gluten intake between 11 and 36 months or the duration of breast feeding were not risk factors for the development of CD in the Spanish population. The HLA genotype and gender were the most relevant associated factors. In this at-risk group, the disease presented before two years of age in the majority of the cases with a weak clinical expression.
    Àrees temàtiques: Odontología Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Gastroenterology & hepatology Gastroenterology Farmacia Ciências biológicas ii Biodiversidade
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 11300108
    Adreça de correu electrònic de l'autor: gemma.castillejo@urv.cat
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.reed.es/ArticuloFicha.aspx?id=2977&hst=0&idR=63&tp=1&AspxAutoDetectCookieSupport=1
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Revista Espanola De Enfermedades Digestivas. 110 (8): 493-499
    Referència de l'ítem segons les normes APA: Crespo Escobar P; Castillejo G; Martínez-Ojinaga E; Donat E; Polanco I; Mearin M; Ribes-Koninckx C (2018). Ten years of follow-up of the Spanish cohort of the European PreventCD study: the lessons learned. Revista Espanola De Enfermedades Digestivas, 110(8), 493-499. DOI: 10.17235/reed.2018.5324/2017
    DOI de l'article: 10.17235/reed.2018.5324/2017
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2018
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Gastroenterology,Gastroenterology & Hepatology,Medicine (Miscellaneous)
    Odontología
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    General medicine
    Gastroenterology & hepatology
    Gastroenterology
    Farmacia
    Ciências biológicas ii
    Biodiversidade
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