Autor segons l'article: Tomas, Josep; Garcia, Neus; Lanuza, Maria A; Santafe, Manel M; Tomas, Marta; Nadal, Laura; Hurtado, Erica; Simo-Olle, Anna; Cilleros-Mane, Vctor; Just-Borras, Laia
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Hurtado Caballero, Erica / Just Borràs, Laia / Lanuza Escolano, María Angel / NADAL MAGRIÑÀ, LAURA / Santafé Martínez, Manuel / SIMÓ OLLÉ, ANNA / Tomás Ferré, José Maria / Tomas Marginet, Marta
Paraules clau: Trkb Postnatal synapse elimination Neurotrophins Muscarinic acetylcholine receptors Motor end-plate Axonal competition Adenosine receptors Acetylcholine release trkb neurotrophins muscarinic acetylcholine receptors motor end-plate axonal competition adenosine receptors acetylcholine release
Resum: © 2018 Tomàs, Garcia, Lanuza, Santafé, Tomàs, Nadal, Hurtado, Simó-Ollé, Cilleros-Mañé and Just-Borràs. In the last few years, we have studied the presence and involvement in synaptogenesis and mature transmitter release of the adenosine autoreceptors (AR) in the mammalian neuromuscular junction (NMJ). Here, we review and bring together the previously published data to emphasize the relevance of these receptors for developmental axonal competition, synaptic loss and mature NMJ functional modulation. However, in addition to AR, activity-dependent mediators originating from any of the three cells that make the synapse (nerve, muscle, and glial cells) cross the extracellular cleft to generate signals in target metabotropic receptors. Thus, the integrated interpretation of the complementary function of all these receptors is needed. We previously studied, in the NMJ, the links of AR with mAChR and the neurotrophin receptor TrkB in the control of synapse elimination and transmitter release. We conclude that AR cooperate with these receptors through synergistic and antagonistic effects in the developmental synapse elimination process. In the adult NMJ, this cooperation is manifested so as that the functional integrity of a given receptor group depends on the other receptors operating normally (i.e., the functional integrity of mAChR depends on AR operating normally). These observations underlie the relevance of AR in the NMJ function.
Àrees temàtiques: Psicología Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Medicina veterinaria Medicina ii Medicina i Interdisciplinar Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16639812
Adreça de correu electrònic de l'autor: laia.just@urv.cat marta.tomas@urv.cat erica.hurtado@urv.cat victor.cilleros@alumni.urv.cat josepmaria.tomas@urv.cat laia.just@urv.cat mariaangel.lanuza@urv.cat manuel.santafe@urv.cat
Identificador de l'autor: 0000-0003-0473-3730 0000-0002-4151-1697 0000-0001-5690-9932 0000-0002-0406-0006 0000-0003-0473-3730 0000-0003-4795-4103 0000-0002-5462-5108
Data d'alta del registre: 2024-10-12
Volum de revista: 9
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.frontiersin.org/articles/10.3389/fphar.2018.00397/full
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Frontiers In Pharmacology. 9 (397): 397-
Referència de l'ítem segons les normes APA: Tomas, Josep; Garcia, Neus; Lanuza, Maria A; Santafe, Manel M; Tomas, Marta; Nadal, Laura; Hurtado, Erica; Simo-Olle, Anna; Cilleros-Mane, Vctor; Just (2018). Adenosine receptors in developing and adult mouse neuromuscular junctions and functional links with other metabotropic receptor pathways. Frontiers In Pharmacology, 9(397), 397-. DOI: 10.3389/fphar.2018.00397
DOI de l'article: 10.3389/fphar.2018.00397
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Pàgina inicial: 397
Tipus de publicació: Journal Publications