Articles producció científica> Enginyeria Química

Developing Integrated PBPK/PD Coupled mechanistic pathway model (miRNA-BDNF): an approach towards System toxicology

  • Dades identificatives

    Identificador: imarina:4683193
    Autors:
    Prasad Sharma, RajuSchuhmacher, MartaKumar, Vikas
    Resum:
    Integration of a dynamic signal transduction pathway into the tissue dosimetry model is a major advancement in the area of computational toxicology. This paper illustrates the ways to incorporate the use of existing system biological model in the field of toxicology via its coupling to the Physiological based Pharmacokinetics and Pharmacodynamics (PBPK/PD) model. This expansion framework of integrated PBPK/PD coupled mechanistic system pathway model can be called as system toxicology that describes the kinetics of both - the chemicals and - biomolecules, help us to understand the dynamic and steady-state behaviors of molecular pathways under perturbed condition. The objective of this article is to illustrate a system toxicology based approach by developing an integrated PBPK/PD coupled miRNA-BDNF pathway model and to demonstrate its application by taking a case study of the PFOS mediated neurotoxicity. System dynamic involves miRNA-mediated BDNF regulation, which plays an important role in the control of neuronal cell proliferation, differentiation, and survivability.
  • Altres:

    Autor segons l'article: Prasad Sharma, Raju; Schuhmacher, Marta; Kumar, Vikas;
    Departament: Enginyeria Química
    Autor/s de la URV: Kumar, Vikas / Schuhmacher Ansuategui, Marta
    Paraules clau: System biology Physiologically-based pharmacokinetic (pbpk) model Pfos Perfluorooctane sulfonate (pfos) Pbpk/pd Neuroendocrine Mirna Bdnf system biology pfos pbpk/pd neuroendocrine bdnf
    Resum: Integration of a dynamic signal transduction pathway into the tissue dosimetry model is a major advancement in the area of computational toxicology. This paper illustrates the ways to incorporate the use of existing system biological model in the field of toxicology via its coupling to the Physiological based Pharmacokinetics and Pharmacodynamics (PBPK/PD) model. This expansion framework of integrated PBPK/PD coupled mechanistic system pathway model can be called as system toxicology that describes the kinetics of both - the chemicals and - biomolecules, help us to understand the dynamic and steady-state behaviors of molecular pathways under perturbed condition. The objective of this article is to illustrate a system toxicology based approach by developing an integrated PBPK/PD coupled miRNA-BDNF pathway model and to demonstrate its application by taking a case study of the PFOS mediated neurotoxicity. System dynamic involves miRNA-mediated BDNF regulation, which plays an important role in the control of neuronal cell proliferation, differentiation, and survivability.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Toxicology Saúde coletiva Química Psicología Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Historia Geociências General medicine Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: vikas.kumar@urv.cat marta.schuhmacher@urv.cat
    Identificador de l'autor: 0000-0002-9795-5967 0000-0003-4381-2490
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S037842741731161X
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Toxicology Letters. 280 79-91
    Referència de l'ítem segons les normes APA: Prasad Sharma, Raju; Schuhmacher, Marta; Kumar, Vikas; (2017). Developing Integrated PBPK/PD Coupled mechanistic pathway model (miRNA-BDNF): an approach towards System toxicology. Toxicology Letters, 280(), 79-91. DOI: 10.1016/j.toxlet.2017.08.003
    DOI de l'article: 10.1016/j.toxlet.2017.08.003
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Toxicology
    System biology
    Physiologically-based pharmacokinetic (pbpk) model
    Pfos
    Perfluorooctane sulfonate (pfos)
    Pbpk/pd
    Neuroendocrine
    Mirna
    Bdnf
    system biology
    pfos
    pbpk/pd
    neuroendocrine
    bdnf
    Zootecnia / recursos pesqueiros
    Toxicology
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Historia
    Geociências
    General medicine
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
  • Documents:

  • Cerca a google

    Search to google scholar