Autor segons l'article: Magyar, C; Gromiha, MM; Pujadas, G; Tusnady, GE; Simon, I;
Departament: Bioquímica i Biotecnologia
e-ISSN: 1362-4962
Autor/s de la URV: Pujadas Anguiano, Gerard
Paraules clau: Long-range interactions Identification Folded proteins Centers
Resum: Residues expected to play key roles in the stabilization of proteins [stabilizing residues (SRs)] are selected by combining several methods based mainly on the interactions of a given residue with its spatial, rather than its sequential neighborhood and by considering the evolutionary conservation of the residues. A residue is selected as a stabilizing residue if it has high surrounding hydrophobicity, high long-range order, high conservation score and if it belongs to a stabilization center. The definition of all these parameters and the thresholds used to identify the SRs are discussed in detail. The algorithm for identifying SRs was originally developed for TIM-barrel proteins [M. M. Gromiha, G. Pujadas, C. Magyar, S. Selvaraj, and I. Simon (2004), Proteins, 55, 316-329] and is now generalized for all proteins of known 3D structure. SRs could be applied in protein engineering and homology modeling and could also help to explain certain folds with significant stability. The SRide server is located at http://sride.enzim.hu.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Nutrição Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Genetics Farmacia Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0305-1048
Adreça de correu electrònic de l'autor: gerard.pujadas@urv.cat
Identificador de l'autor: 0000-0003-2598-8089
Pàgina final: W305
Data d'alta del registre: 2023-02-18
Volum de revista: 33
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://academic.oup.com/nar/article/33/suppl_2/W303/2505549
Referència a l'article segons font original: Nucleic Acids Research. 33 (Supl 2): W303-W305
Referència de l'ítem segons les normes APA: Magyar, C; Gromiha, MM; Pujadas, G; Tusnady, GE; Simon, I; (2005). SRide: a server for identifying stabilizing residues in proteins. Nucleic Acids Research, 33(Supl 2), W303-W305. DOI: 10.1093/nar/gki409
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1093/nar/gki409
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2005
Pàgina inicial: W303
Tipus de publicació: Journal Publications
Repositori URV