Articles producció científica> Bioquímica i Biotecnologia

Different papillomaviruses have different repertoires of transcription factor binding sites: convergence and divergence in the upstream regulatory region

  • Dades identificatives

    Identificador: imarina:5117355
    Autors:
    García-Vallvé S, Iglesias-Rozas JR, Alonso A, Bravo IG.
    Resum:
    Background: Papillomaviruses (PVs) infect stratified squamous epithelia in warm-blooded vertebrates and have undergone a complex evolutionary process. The control of the expression of the early ORFs in PVs depends on the binding of cellular and viral transcription factors to the upstream regulatory region (URR) of the virus. It is believed that there is a core of transcription factor binding sites (TFBS) common to all PVs, with additional individual differences, although most of the available information focuses only on a handful of viruses. Results: We have studied the URR of sixty-one PVs, covering twenty different hosts. We have predicted the TFBS present in the URR and analysed these results by principal component analysis and genetic algorithms. The number and nature of TFBS in the URR might be much broader than thus far described, and different PVs have different repertoires of TFBS. Conclusion: There are common fingerprints in the URR in PVs that infect primates, although the ancestors of these viruses diverged a long time ago. Additionally, there are obvious differences between the URR of alpha and beta PVs, despite these PVs infect similar histological cell types in the same host, i.e. human. A thorough analysis of the TFBS in the URR might provide crucial information about the differential biology of cancer-associated PVs.
  • Altres:

    Autor segons l'article: García-Vallvé S, Iglesias-Rozas JR, Alonso A, Bravo IG.
    Departament: Bioquímica i Biotecnologia
    e-ISSN: 1471-2148
    Autor/s de la URV: Garcia Vallve, Santiago
    Paraules clau: Type-18 promoter Multiple sequence alignment Lineages Life Keratinocytes Enhancer Cervical-cancer worldwide Cell-specific transcription
    Resum: Background: Papillomaviruses (PVs) infect stratified squamous epithelia in warm-blooded vertebrates and have undergone a complex evolutionary process. The control of the expression of the early ORFs in PVs depends on the binding of cellular and viral transcription factors to the upstream regulatory region (URR) of the virus. It is believed that there is a core of transcription factor binding sites (TFBS) common to all PVs, with additional individual differences, although most of the available information focuses only on a handful of viruses. Results: We have studied the URR of sixty-one PVs, covering twenty different hosts. We have predicted the TFBS present in the URR and analysed these results by principal component analysis and genetic algorithms. The number and nature of TFBS in the URR might be much broader than thus far described, and different PVs have different repertoires of TFBS. Conclusion: There are common fingerprints in the URR in PVs that infect primates, although the ancestors of these viruses diverged a long time ago. Additionally, there are obvious differences between the URR of alpha and beta PVs, despite these PVs infect similar histological cell types in the same host, i.e. human. A thorough analysis of the TFBS in the URR might provide crucial information about the differential biology of cancer-associated PVs.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Química Medicina veterinaria Medicina i Interdisciplinar Geociências Genetics & heredity Evolutionary biology Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: santi.garcia-vallve@urv.cat
    Identificador de l'autor: 0000-0002-0348-7497
    Data d'alta del registre: 2023-02-18
    Volum de revista: 6
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://bmcecolevol.biomedcentral.com/articles/10.1186/1471-2148-6-20
    Referència a l'article segons font original: Bmc Evolutionary Biology. 6
    Referència de l'ítem segons les normes APA: García-Vallvé S, Iglesias-Rozas JR, Alonso A, Bravo IG. (2006). Different papillomaviruses have different repertoires of transcription factor binding sites: convergence and divergence in the upstream regulatory region. Bmc Evolutionary Biology, 6(), -. DOI: 10.1186/1471-2148-6-20
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1186/1471-2148-6-20
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2006
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Ecology, Evolution, Behavior and Systematics,Evolutionary Biology,Genetics & Heredity
    Type-18 promoter
    Multiple sequence alignment
    Lineages
    Life
    Keratinocytes
    Enhancer
    Cervical-cancer worldwide
    Cell-specific transcription
    Zootecnia / recursos pesqueiros
    Química
    Medicina veterinaria
    Medicina i
    Interdisciplinar
    Geociências
    Genetics & heredity
    Evolutionary biology
    Ecology, evolution, behavior and systematics
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
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