Autor segons l'article: Mar Rodriguez, M.; Perez, Daniel; Javier Chaves, Felipe; Esteve, Eduardo; Marin-Garcia, Pablo; Xifra, Gemma; Vendrell, Joan; Jove, Mariona; Pamplona, Reinald; Ricart, Wifredo; Portero-Otin, Manuel; Chacon, Matilde R.; Fernandez Real, Jose Manuel;
Departament: Medicina i Cirurgia
Autor/s de la URV: Rodríguez Chacón, Matilde / Vendrell Ortega, Juan José
Paraules clau: Microbiome Inflammation Commensal fungi Candida
Resum: The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in obese and non-obese subjects was characterized using Internal Transcribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could be discriminated by their specific fungal composition, which also distinguished metabolically ¿healthy¿ from ¿unhealthy¿ obesity. Clusters according to genus abundance co-segregated with body fatness, fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioic acid, caproic acid and N-acetyl-L-glutamic acid was also found. Mucor racemosus and M. fuscus were the species more represented in non-obese subjects compared to obese counterparts. Interestingly, the decreased relative abundance of the Mucor genus in obese subjects was reversible upon weight loss. Collectively, these findings suggest that manipulation of gut mycobiome communities might be a novel target in the treatment of obesity.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: matilde.rodriguez@urv.cat jvortega@iispv.cat
Identificador de l'autor: 0000-0002-6994-6115
Data d'alta del registre: 2024-11-16
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: http://nportal0.urv.cat:18080/fourrepo/edit.jsp
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Scientific Reports. 5 (14600): 14600-
Referència de l'ítem segons les normes APA: Mar Rodriguez, M.; Perez, Daniel; Javier Chaves, Felipe; Esteve, Eduardo; Marin-Garcia, Pablo; Xifra, Gemma; Vendrell, Joan; Jove, Mariona; Pamplona, (2015). Obesity changes the human gut mycobiome. Scientific Reports, 5(14600), 14600-. DOI: 10.1038/srep14600
DOI de l'article: 10.1038/srep14600
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2015
Tipus de publicació: Journal Publications
Repositori URV