Autor segons l'article: Lopez, Josep M.; Fortuny, Gerard; Puigjaner, Dolors; Herrero, Joan; Marimon, Francesc; Garcia-Bennett, Josep;
Departament: Enginyeria Química Enginyeria Informàtica i Matemàtiques Medicina i Cirurgia
Autor/s de la URV: Fortuny Anguera, Gerard / Herrero Sabartés, Juan / López Besora, Josep Maria / Puigjaner Riba, Maria Dolores
Paraules clau: Wall shear stress International standard thrombotic treatment Deep venous thrombosis Computational fluid dynamics Biomechanical model international standard thrombotic treatment deep venous thrombosis computational fluid dynamics biomechanical model
Resum: Deep venous thrombosis (DVT) is a common disease. Large thrombi in venous vessels cause bad blood circulation and pain; and when a blood clot detaches from a vein wall, it causes an embolism whose consequences range from mild to fatal. Walking is recommended to DVT patients as a therapeutical complement. In this study the mechanical effects of walking on a specific patient of DVT were simulated by means of an unprecedented integration of 3 elements: a real geometry, a biomechanical model of body tissues, and a computational fluid dynamics study. A set of computed tomography images of a patient's leg with a thrombus in the popliteal vein was employed to reconstruct a geometry model. Then a biomechanical model was used to compute the new deformed geometry of the vein as a function of the fiber stretch level of the semimembranosus muscle. Finally, a computational fluid dynamics study was performed to compute the blood flow and the wall shear stress (WSS) at the vein and thrombus walls. Calculations showed that either a lengthening or shortening of the semimembranosus muscle led to a decrease of WSS levels up to 10%. Notwithstanding, changes in blood viscosity properties or blood flow rate may easily have a greater impact in WSS.
Àrees temàtiques: Software Molecular biology Modeling and simulation Medicina ii Medicina i Mathematics, interdisciplinary applications Mathematical & computational biology Interdisciplinar Engineering, biomedical Engenharias iii Engenharias i Educação física Computational theory and mathematics Ciências biológicas ii Ciência da computação Biomedical engineering Applied mathematics
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: gerard.fortuny@urv.cat dolors.puigjaner@urv.cat joan.herrero@urv.cat josep.m.lopez@urv.cat
Identificador de l'autor: 0000-0002-2500-7386 0000-0001-5251-2022 0000-0001-8501-1187 0000-0001-7541-8936
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/10.1002/cnm.2819
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal For Numerical Methods In Biomedical Engineering. 33 (5): e2819-
Referència de l'ítem segons les normes APA: Lopez, Josep M.; Fortuny, Gerard; Puigjaner, Dolors; Herrero, Joan; Marimon, Francesc; Garcia-Bennett, Josep; (2017). Effects of walking in deep venous thrombosis: a new integrated solid and fluid mechanics model. International Journal For Numerical Methods In Biomedical Engineering, 33(5), e2819-. DOI: 10.1002/cnm.2819
DOI de l'article: 10.1002/cnm.2819
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Tipus de publicació: Journal Publications