Autor segons l'article: Sanchez-Lopez, Elena; Ettcheto, Miren; Antonia Egea, Maria; Espina, Marta; Cristina Calpena, Ana; Folch, Jaume; Camins, Antoni; Luisa Garcia, Maria
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Folch Lopez, Jaume
Paraules clau: Polyglactin 910; Polyethylene glycols; Poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer; Plga-peg; Ocular delivery; Nanospheres; Nanoparticles; Mouse model; Mice, inbred c57bl; Mice; Memory; Male; Lipid nanoparticles; In-vitro; Ibuprofen; Flurbiprofen; Ex-vivo; Drug-release; Drug carriers; Dried plga nanoparticles; Disease models, animal; Dexibuprofen; Design; Coculture techniques; Cell line; Brain; Blood–brain barrier; Blood-brain-barrier; Blood-brain barrier; Anti-inflammatory agents, non-steroidal; Animals; Alzheimer's disease; Alzheimer disease; nanospheres; nanoparticles; dexibuprofen; blood–brain barrier; alzheimer's disease
Resum: Dexibuprofen loaded pegylated poly(lactic-co-glycolic) nanospheres prepared by solvent diffusion method were designed to increase Dexibuprofen brain delivery reducing systemic side effects. Nanospheres exhibited a mean particle size around 200 nm (195.4 nm), monomodal population and negative surface charge. Drug loaded nanospheres showed a sustained release profile, allowing to modify the posology in vivo. Nanospheres were non-toxic neither in brain endothelial cells nor astrocytes and do not cause blood¿brain barrier disruption. Nanospheres were able to partially cross the cells barrier and release the drug after co-culture in vitro experiments, increasing Dexibuprofen permeation coefficient. Behavioral tests performed in APPswe/PS1dE9 mice (mice model of familial Alzheimer's disease) showed that nanospheres reduce memory impairment more efficiently than the free drug. Developed nanospheres decrease brain inflammation leading to ¿-amyloid plaques reduction. According to these results, chronical oral Dexibuprofen pegylated poly(lactic-co-glycolic) nanosystems could constitute a suitable strategy for the prevention of neurodegeneration.
Àrees temàtiques: Química; Psicología; Pharmaceutical science; Odontología; Nanoscience and nanotechnology; Nanoscience & nanotechnology; Molecular medicine; Medicine, research & experimental; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materials science (miscellaneous); Materials science (all); Materiais; Interdisciplinar; General medicine; General materials science; Farmacia; Engenharias iv; Engenharias iii; Engenharias ii; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Biotecnología; Biomedical engineering; Bioengineering; Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 15499634
Adreça de correu electrònic de l'autor: jaume.folch@urv.cat
Data d'alta del registre: 2024-10-19
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S1549963416302209?via%3Dihub
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Nanomedicine-Nanotechnology Biology And Medicine. 13 (3): 1171-1182
Referència de l'ítem segons les normes APA: Sanchez-Lopez, Elena; Ettcheto, Miren; Antonia Egea, Maria; Espina, Marta; Cristina Calpena, Ana; Folch, Jaume; Camins, Antoni; Luisa Garcia, Maria (2017). New potential strategies for Alzheimer's disease prevention: pegylated biodegradable dexibuprofen nanospheres administration to APPswe/PS1dE9. Nanomedicine-Nanotechnology Biology And Medicine, 13(3), 1171-1182. DOI: 10.1016/j.nano.2016.12.003
DOI de l'article: 10.1016/j.nano.2016.12.003
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Tipus de publicació: Journal Publications
Repositori URV