Contribution of Oxidative Stress to Non-AIDS Events in HIV-Infected Patients

Autor segons l'article: Masia, Mar; Padilla, Sergio; Fernandez, Marta; Barber, Xavier; Moreno, Santiago; Antonio Iribarren, Jose; Portilla, Joaquin; Pena, Alejandro; Vidal, Francesc; Gutierrez, Felix

Departament: Medicina i Cirurgia

Autor/s de la URV: Vidal Marsal, Francisco

Paraules clau: Renal insufficiency Reactive oxygen species Prospective studies Prognosis Pro-oxidant status Oxidative stress Nonroutine biomarkers Neoplasms Middle aged Male Liver cirrhosis Intervention Interleukin-6 Inflammation Il6 protein, human Humans Hiv pathogenesis Hiv infections Fibrin fragment d Fibrin fibrinogen degradation products Female F2-isoprostanes Cause of death Cardiovascular diseases C-reactive protein Biomarkers Adult

Resum: OBJECTIVE: Recognition of potentially modifiable mechanisms implicated in the pathogenesis of non-AIDS events (NAEs) might help improve outcomes of HIV-infected individuals. HIV infection has been associated with increased oxidative stress. We assessed the association between F2-isoprostanes and serious NAEs, and whether they improve the predictive performance of inflammation and coagulation biomarkers. METHODS: Prospective multicenter cohort. Individuals who had an incident serious NAE and 2 sex- and age-matched participants with no events were selected. Measurement of F2-isoprostanes, highly sensitive C-reactive protein, interleukin-6, D-dimer, sCD14, sCD40, sCD163, and neopterin levels was performed in successive plasma samples collected from cohort inclusion. RESULTS: Biomarkers were measured in 78 participants developing serious NAEs or death, and 151 subjects with no events. Adjusted levels of F2-isoprostanes, and also of highly sensitive C-reactive protein, sCD14, and D-dimer were higher in individuals who developed serious NAEs, including or not non-AIDS deaths. The same results were observed when only samples collected since the time of achieving virological suppression were analyzed. The additive incorporation of each biomarker, ending with F2-isoprostanes, in an adjusted model was associated with a graded and significant increase in the quality of model fitting, and 94% sensitivity, 33% specificity, and 0.77 accuracy to predict serious NAEs including non-AIDS-related death. CONCLUSION: Oxidative stress is associated with a higher risk of serious NAEs, including non-AIDS deaths. This effect is independent and additive to biomarkers of inflammation, monocyte activation, and coagulation. Our results suggest that oxidative stress should be included among mechanisms to deal with to improve prognosis of HIV-infected individuals.

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1525-4135

Adreça de correu electrònic de l'autor: francesc.vidal@urv.cat

Identificador de l'autor: 0000-0002-6692-6186

Data d'alta del registre: 2025-02-18

Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

Referència a l'article segons font original: Journal Of Acquired Immune Deficiency Syndromes (Jaids). 75 (2): e36-e44

Referència de l'ítem segons les normes APA: Masia, Mar; Padilla, Sergio; Fernandez, Marta; Barber, Xavier; Moreno, Santiago; Antonio Iribarren, Jose; Portilla, Joaquin; Pena, Alejandro; Vidal, F (2017). Contribution of Oxidative Stress to Non-AIDS Events in HIV-Infected Patients. Journal Of Acquired Immune Deficiency Syndromes (Jaids), 75(2), e36-e44. DOI: 10.1097/QAI.0000000000001287

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2017

Tipus de publicació: Journal Publications