Autor segons l'article: Gonzalez, Beatriz; Mas, Albert; Beltran, Gemma; Cullen, Paul J.; Jesus Torija, Maria;
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Beltran Casellas, Gemma / Mas Baron, Alberto / Torija Martínez, María Jesús
Paraules clau: Quorum sensing Pseudohyphal growth Mitochondria-to-nucleus pathway Krebs cycle Filamentous growth pseudohyphal growth mitochondria-to-nucleus pathway krebs cycle filamentous growth
Resum: In yeast, ethanol is produced as a by-product of fermentation through glycolysis. Ethanol also stimulates a developmental foraging response called filamentous growth and is thought to act as a quorum-sensing molecule. Ethanol-inducible filamentous growth was examined in a small collection of wine/European strains, which validated ethanol as an inducer of filamentous growth. Wine strains also showed variability in their filamentation responses, which illustrates the striking phenotypic differences that can occur among individuals. Ethanol-inducible filamentous growth in 61278b strains was independent of several of the major filamentation regulatory pathways [including fMAPK, RAS-cAMP, Snf1, Rpd3(L), and Rim101] but required the mitochondrial retrograde (RTG) pathway, an inter-organellar signaling pathway that controls the nuclear response to defects in mitochondrial function. The RTG pathway regulated ethanol-dependent filamentous growth by maintaining flux through the TCA cycle. The ethanol-dependent invasive growth response required the polarisome and transcriptional induction of the cell adhesion molecule Flo11p. Our results validate established stimuli that trigger filamentous growth and show how stimuli can trigger highly specific responses among individuals. Our results also connect an inter-organellar pathway to a quorum sensing response in fungi.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Physiology (medical) Physiology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Ensino Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: albert.mas@urv.cat mjesus.torija@urv.cat gemma.beltran@urv.cat
Identificador de l'autor: 0000-0002-0763-1679 0000-0001-6419-0745 0000-0002-7071-205X
Data d'alta del registre: 2023-09-16
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.frontiersin.org/articles/10.3389/fphys.2017.00148/full
Referència a l'article segons font original: Frontiers In Physiology. 8 (MAR): 148-
Referència de l'ítem segons les normes APA: Gonzalez, Beatriz; Mas, Albert; Beltran, Gemma; Cullen, Paul J.; Jesus Torija, Maria; (2017). Role of Mitochondrial Retrograde Pathway in Regulating Ethanol-Inducible Filamentous Growth in Yeast. Frontiers In Physiology, 8(MAR), 148-. DOI: 10.3389/fphys.2017.00148
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.3389/fphys.2017.00148
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Tipus de publicació: Journal Publications
Repositori URV