Articles producció científica> Ciències Mèdiques Bàsiques

Review of the treatment of Graves' ophthalmopathy: The role of the new radiation techniques

  • Dades identificatives

    Identificador: imarina:5132742
    Autors:
    San Miguel I, Arenas M, Carmona R, Rutllan J, Medina-Rivero F, Lara P.
    Resum:
    Graves ophthalmopathy (GO) is an autoimmune disorder and the most frequent extrathyroidal manifestation of Graves' disease. GO is an inflammatory process leading to an increased volume of the extraocular muscles and orbital connective and adipose tissues associated with multiple histopathological changes. Despite recent progress in the understanding of its pathogenesis, GO often remains a major diagnostic and therapeutic challenge. It has become increasingly important to classify patients into categories based on disease severity and activity. Low doses of radiotherapy (RT) have demonstrated a benefit in the treatment of moderate-to-severe GO with very few side effects. New RT techniques deliver a more conformal dose distribution to the target and decrease the dose to normal healthy tissue minimizing the risk of side effects. In this review we briefly analyzed the pathogenesis of GO and discussed the most relevant therapeutic approaches, with particular emphasis in the new RT technics. Appropriately designed and powered clinical studies are necessary to determine the most effective treatment with the lowest risk of side effects.
  • Altres:

    Autor segons l'article: San Miguel I, Arenas M, Carmona R, Rutllan J, Medina-Rivero F, Lara P.
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Arenas Prat, Meritxell
    Paraules clau: Toxicity Radiotherapy Graves’ opthalmopathy radiotherapy graves’ opthalmopathy
    Resum: Graves ophthalmopathy (GO) is an autoimmune disorder and the most frequent extrathyroidal manifestation of Graves' disease. GO is an inflammatory process leading to an increased volume of the extraocular muscles and orbital connective and adipose tissues associated with multiple histopathological changes. Despite recent progress in the understanding of its pathogenesis, GO often remains a major diagnostic and therapeutic challenge. It has become increasingly important to classify patients into categories based on disease severity and activity. Low doses of radiotherapy (RT) have demonstrated a benefit in the treatment of moderate-to-severe GO with very few side effects. New RT techniques deliver a more conformal dose distribution to the target and decrease the dose to normal healthy tissue minimizing the risk of side effects. In this review we briefly analyzed the pathogenesis of GO and discussed the most relevant therapeutic approaches, with particular emphasis in the new RT technics. Appropriately designed and powered clinical studies are necessary to determine the most effective treatment with the lowest risk of side effects.
    Àrees temàtiques: Ophthalmology Medicina iii Medicina i
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 13194534
    Adreça de correu electrònic de l'autor: meritxell.arenas@urv.cat
    Identificador de l'autor: 0000-0003-0815-2570
    Data d'alta del registre: 2023-04-01
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/pii/S1319453417301133
    Referència a l'article segons font original: Saudi Journal Of Ophthalmology. 32 (2): 139-145
    Referència de l'ítem segons les normes APA: San Miguel I, Arenas M, Carmona R, Rutllan J, Medina-Rivero F, Lara P. (2018). Review of the treatment of Graves' ophthalmopathy: The role of the new radiation techniques. Saudi Journal Of Ophthalmology, 32(2), 139-145. DOI: 10.1016/j.sjopt.2017.09.003
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1016/j.sjopt.2017.09.003
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2018
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Ophthalmology
    Toxicity
    Radiotherapy
    Graves’ opthalmopathy
    radiotherapy
    graves’ opthalmopathy
    Ophthalmology
    Medicina iii
    Medicina i
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